Dr. Amit Khairnar

PDF: University of Auvergne, Clermont Ferrand,France- December 2012

PDF: CEITEC, Masaryk University, Brno,Czech Republic. – Sep 2017

Ph.D: University of Cagliari, Cagliari, Italy, February 2011.


Dr. Amit Khairnar

Assistant Professor

Tele : +91-919284349396

E-mail : amitk.nipera@gmail.com ,amitkhairnar520@gmail.com

Research Interest

Dr.Khairnar research focus is development of neurorpotective therapy which may halt or reverse the progression of Parkinsons disease (PD). He is also interested in detecting role of neuroinflammation in transferring alpha synuclein from one neuron to other. He has experience of both transgenic and toxin based mouse model of PD. Currently he is working with intragastric rotenone model in which alpha synucelin accumulation starts from enteric neurons and progresses to substantia nigra. His goal is to study newer agents first in vitro on enteric neurons treated with rotenone and later test them on in vivo rotenone model. Dr.Khairnar has wide expertise in behavioural studies, immunohistochemistry, western blot, in vitro cell culture, PET, SPECT, CT and MRI imaging.

Experience

    • September 2017 - Present:
      Assistant Professor (Pharmacology and Toxicology), NIPER-Ahmedabad, Gandhinagar, Gujarat, India
    • February 2013 – August 2017 :
      Postdoctoral Research Fellow, CEITEC, Masaryk University, Brno, Czech Republic
    • January 2012 - December 2012:
      Postdoctoral Research Fellow, University of Auvergne, Clermont-Ferrand, France.
    • August 2011 - December 2011:
      Assistant Professor, MGV college of Pharmacy, Nashik, India
    • September 2007 - February 2011:
      Ministry of Italian University Research Fellow, University of Cagliari, Cagliari, Italy.

Honours/Awards/Grants/Consultancies

Awards

  • Received IBRO travel grant to participate in 8th world congress of IBRO Florence Italy (2011).
  • Received WPC 2010 TRAVEL GRANT to participate in 2nd World Parkinson Congress (2010) Glasgow, Scotland, UK.
  • Three years Young Indian Researcher fellowship (2007—2010) from the Ministry of Italian University of Research (MIUR), Italy
  • Received FENS travel grant to attend satelline symposium on neurodegenerative disorders (2014), Baveno, Italy

Grants

  • Marie Curie Fellowship (2015 – 2016) Title: Identification of Magnetic resonance imaging biomarker for early diagnosis of Parkinson’s disease.
  • Grant Amount: 1,46,000 Euro
  • Role:Principal Investigator

Publications

  • Anas Arab, Anna Wojna-Pelczar, Amit Khairnar, Nikoletta Szabó, Jana Ruda-Kucerova. (2018) Principles of diffusion kurtosis imaging and its role in early diagnosis of neurodegenerative disorders, Brain Research Bulletin. 139, 91-98. https://doi.org/10.1016/j.brainresbull.2018.01.015
  • Khairnar A, Ruda-Kucerova J, Szabó N, Drazanova E, Arab A, Hutter-Paier B, Joerg Neddens, Latta P, Starcuk Z Jr, Rektorova I. (2016) Early and progressive brain microstructural changes in mice overexpressing human α-Syn detected by the diffusion kurtosis imaging. Brain Behav Immun. pii: S0889-1591(16)30529-3.
  • Khairnar A, Ruda-Kucerova J, Drazanova E, Szabó N, Latta P, Arab A, Hutter-Paier B, Havas D, Windisch M, Sulcova A, Starcuk Z Jr, Király A, Rektorova I. (2015) Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson's disease detected by diffusion kurtosis imaging. J Neurochem. 2015 Dec 19. doi: 10.1111/jnc.13500. (This article got editorial highlight – Williams S et al., 2016).
  • Moratalla R, Khairnar A, Simola N, Granado N, García-Montes JR, Porceddu PF, Tizabi Y, Costa G, Morelli M (2015) Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms. Prog Neurobiol. 2015 Oct 9. pii: S0301-0082(15)00100-8.
  • Frau L, Costa G, Porceddu PF, Khairnar A, Castelli MP, Ennas MG, Madeddu C, Wardas J, Morelli M. (2015) Influence of caffeine on 3,4-methylenedioxymethamphetamine (MDMA)-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent. J Neurochem. 2015 Oct 7. doi: 10.1111/jnc.13377
  • Khairnar A, Latta P, Drazanova E, Ruda-Kucerova J, Szabó N, Arab A, Hutter-Paier B, Havas D, Windisch M, Sulcova A, Starcuk Z Jr, Rektorova I. (2015) Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson's Disease: A Pilot Study.Neurotox Res. 2015 Nov;28(4):281-9
  • Amit Khairnar, Fabien Marchand, Aurélien Vidal, Monique Etienne, Imen Miladi, Philippe Auzeloux, Florent Cachin, Alain Eschalier, Jean-Michel Chezal, Denis Ardid, and Elisabeth Miot-Noirault (2015) 99mTc-NTP 15-5 Imaging for Cartilage Involvement in Experimental Rheumatoid Arthritis: Comparison with Routinely Used Molecular Imaging Methods and Sensitivity to Chronic Nonsteroidal Antiinflammatory Drug Treatment. J Nucl Med. 56(5):798-804
  • Amit Khairnar, Lucia Frau, Antonio Plumitallo, Micaela Morelli, and Nicola Simola. Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of MDMA on Glial Activation in the Mouse Brain: Relevance to Caffeine–MDMA Interactions. J Caffeine Res. 2014 Volume 4 (2) (DOI: 10.1089/jcr.2014.0006).
  • Amit Khairnar, A. Plumitallo, L. Frau, N. Schintu, M. Morelli: Caffeine Enhances Astroglia and Microglia Reactivity Induced by 3, 4 Methylenedioxymethamphetamine (‘Ecstasy’) in Mouse Brain. Neurotox. Res., 17, 4, 2010.
  • Lucia Frau, Franco Borsini, Jadwiga Wardas, Amit Khairnar, Nicoletta Schintu, Micaela Morelli: Neuroprotective and anti-inflammatory effects of the new adenosine A2A receptor antagonist ST1535 in a MPTP mouse model of Parkinson’s disease, Synapse, July 2010.
Presentations:
International: 07
Projects:
Completed: 01
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