Amit Shard, Ph. D


Amit Sharad, Ph.D

Assistant Professor

Tele :+91 79 66745555

E-mail :

Research Interest

Development of novel and eco-sustainable tandem protocols for bioactive (anticancer and antimicrobial) molecules.

Design, synthesis, computational validation of hetero (aromatic) molecules with drug like properties targeted towards cancer. In area of cancer, our group is focusing on finding potential lead molecules against tumor M2 Pyruvate Kinase (M2PK) enzyme having widespread occurrence in several cancer types. Targeting this enzyme with potent and selective agents will thwart the progression of cancer.

Our group is also working on development of thiazole based small molecule BCL2 inhibitors.


  • June 2014-Present: Assistant Professor, NIPER-Ahmedabad, Palaj Gandhinagar
  • April, 2011-April 2014: Senior Research Fellowship, by Council of Scientific and Industrial Research, New Delhi.
  • July 2008-March 2011: Project Assistantship, CSIR-IHBT, Palampur, H.P



  • Young Achiever Award-2016, by SBSOSA, S.B.S. P.G.I, Dehradoon.
  • Recent work published in European Journal of Organic Chemistry (2016) was highlighted in the form of video by the journal. The work was considered highly significant.
  • Central Drug Research Institute awarded CDRI-Research Incentive Award -2016.
  • Best poster award- 2013 on at B.H.U Varanasi in conference organized by Chemical Research society (CRSI) of India.
  • Award by the Institute of Himalayan Bioresource Technology, Palampur on national science day (28th of Feb) for publishing an article in Angew. Chem. Int. Edn (2013)..
  • Dr. P. D. Sethi annual award-2012 for best research paper (Angew. Chem. Int. Edn. 2012, 51, 2636-39) on Application of HPTLC in Pharma, Herbal and other Chemical Analysis.
  • Award by the Institute of Himalayan Bioresource Technology, Palampur on National Science Day (28th of Feb) for publishing an article in Angew. Chem. Int. Edn (2012).
  • Best poster award at CRSI North Zone meeting, at Jammu University (2011).


  • Amit Shard, Kiran Rawat, Arun K. Sinha, Yogendra Padwad and Dinesh Kumar. Divergent synthesis of styryl–cinnamate hybrid analogues inspired by the natural product salvianolic acid F as a premise to investigate their anticancer activity and its metabolomic profiling. Eur. J. Org. Chem.5941-5949 (2016). DOI: 10.1002/ejoc.201601104.
  • S. Bhute, D. Sarmah, P. Rane,Amit Shard, A. Goswami, A. Borah, K. Kalia, K. R Dave, P. Bhattacharya,. Interventional Strategies for Alzheimer's disease: Emerging novel therapeutic targets for future implications (2018). Molecular Neurobiology (Just Accepted)
  • Amit Shard, Rajesh Kumar, Danish Iqubal and Arun K Sinha. Pot-economy synthesis of hydroxylated arylethenyl-arylethynyl-arenes through sequencial decarboxylative Perkin-Sonogashira reactions. Asian Journal of Organic Chemistry, 7:189-196 (2018), DOI: 10.1002/ajoc.201700504.
  • Rini Jarial, Sveta Thakur, Mimi Sakinah, A.W. Zularisam, Amit Shard, S.S. Kanwar, Lakhveer Singh. Potent anticancer, antioxidant and antibacterial activities of isolated flavonoids from Asplenium nidus.. Journal of King Saud University–Science(2016), .
  • Rini Jarial, Amit Shard, Sveta Thakur, Mimi Sakinah, A.W. Zularisam, Shahabaldin Rezania, S.S. Kanwar and Lakhveer Singh. Characterization of flavonoids from fern Cheilanthes tenuifolia and evaluation of antioxidant, antimicrobial and anticancer activities. Journal of King Saud University – Science (2017),
  • Amit Shard, Kiran Rawat, Arun K. Sinha, Yogendra Padwad and Dinesh Kumar. Natural product Salvianolic acid F-inspired divergent synthesis of styryl-cinnamate hybrid analogues as a premise to investigate anticancer activity and its metabolomic profiling. (2016) Eur. J. Org. Chem. 10.1002/ejoc.201601104.
  • Rajesh Kumar, Saima, Amit Shard, Nitin H. Andhare, Richa & ArunK. Sinha.Thiol–Ene "Click” Reaction Triggered by Neutral Ionic Liquid: The "Ambiphilic” Character of [hmim] Br in the Regioselective Nucleophilic Hydrothiolation. Angewandte Chemie International Edition, 54: 828–832 (2015). DOI: 10.1002/anie.201408721
  • Amit Shard, Rajesh Kumar, Nidhi Sharma & Arun K. Sinha. Amino acid and water-driven tunable green protocol to access S–S/C–S bonds via aerobic oxidative coupling and hydrothiolation. RSC Advances, 4: 33399-33407 (2014). DOI: 10.1039/C4RA02909G
  • Rajesh Kumar, Nitin H Andhare, Amit Shard, Richa & Arun K Sinha. Multicomponent diversity-oriented synthesis of symmetrical and unsymmetrical 1,4-dihydropyridines in recyclable glycine nitrate (GlyNO3) ionic liquid: a mechanistic insight using Q-TOF, ESI-MS/MS. RSC Adv., 4: 19111-19121 (2014). DOI: 10.1039/C4RA02169J
  • Rajesh Kumar, Richa , Nitin H. Andhare , Amit Shard & Arun K. Sinha. Water compatible multicomponent cascade Suzuki/Heck–Aldol, Suzuki–Aldol–Suzuki, and Aldol–Suzuki–Aldol Reactions: An ecofriendly paradigm for multiple carbon=carbon bond formation in one pot. Chemistry-A European Journal, 19: 14798–14803 (2013). DOI: 10.1002/chem.201303069
  • Naina Sharma , Dinesh Mohanakrishnan, Amit Shard, Abhishek Sharma & Arun K. Sinha and Dinkar Sahal. Stilbene-Chalcone hybrids: Design, synthesis, and evaluation as a new class of antimalarial scaffolds that trigger cell death through stage specific apoptosis. Journal of Medicinal Chemistry, 55: 297–311 (2012). DOI: 10.1021/jm201216y
  • Rakesh Kumar, Prabha Sharma, Amit Shard, Dhananjay Kumar Tewary, Gireesh Nadda, & Arun Kumar Sinha. Chalcones as promising pesticidal agents against diamondback moth (Plutella xylostella): microwave-assisted synthesis and structure–activity relationship. Medicinal Chemistry Research, 21: 922–931 (2012). DOI 10.1007/s00044-011-9602-8
  • Amit Shard, Naina Sharma, Richa Bharti, Sumit Dadhwal, Rajesh Kumar & Arun K. Sinha. Tandem Heck/Decarboxylation/Heck strategy: Protecting-group-free synthesis of symmetric and unsymmetric hydroxylated stilbenoids. Angewandte Chemie International Edition,51: 12250–12253 (2012) DOI: 10.1002/anie.201206346
  • Rakesh Kumar, Amit Shard, Richa Bharti, Yogesh Thopate & Arun Kumar Sinha. Palladium-catalyzed dehydrative Heck olefination of secondary aryl alcohols in ionic liquids: Towards a waste-free strategy for tandem synthesis of stilbenoids. Angewandte Chemie International Edition, 51: 2636–2639 (2012). DOI:10.1002/anie.201107261
  • Rajesh Kumar, Nandini Sharma, Upendra K. Sharma, Amit Shard & Arun K. Sinha. First metal and base-free selective oxidative coupling of thiols in neat ionic liquids: NMR probed "Ambiphilic” character of neutral [hmim]Br towards atom-efficient synthesis of disulfides. Advanced Synthesis & Catalysis, 35: 2107–2112 (2012). DOI: 10.1002/adsc.201200190
  • Abhishek Sharma, Naina Sharma, Rakesh Kumar, Amit Shard & Arun K. Sinha. Direct olefination of benzaldehydes into hydroxy functionalized oligo (p-phenylenevinylene)s via Pd-catalyzed heterodomino Knoevenagel-decarboxylation-Heck sequence and its application for fluoride sensing p-conjugated units. Chemical Communications, 46: 3283-3285 (2010). DOI:10.1039/C001980A
Complete list
MS Dissertation:
Completed : 4
Ongoing: 4
Ongoing: 1
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