Rakesh Kumar Tekade, Ph. D

PDF: UT Southwestern Medical Centre, Dallas, Texas, USA

PDF: University of Hawaii, Hilo, Hawaii, USA

Commonwealth Split Site Ph. D Fellow:University of Central Lancashire, Preston, UK (2009)

Ph.D: Dr Hari Singh Gour Central University, Sagar, India (2011)


Rakesh Kumar Tekade, Ph. D

Assistant Professor

Tele: +91 79 66745555

E-mail : rakeshtekade@gmail.com,rakeshtekade@niperahm.ac.in

Research Interest

Dr. Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development, and characterization of targeted nanotechnology-based formulations for the site-specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins, and peptides for the treatment of cancer. An overarching goal of his current research interests encompass development of novel polymeric nanomaterial for effective cytosolic delivery of gene therapeutics. Dr.Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Tekade has also investigated the anticancer activity and molecular mechanism of several compounds and nanoformulations against cancer cell lines and tumorogenic mouse models. Dr.Tekade has >90 publications (>2200 citations; H–index of 23; cumulative Impact Factor: 315.10), 01 patent, 20 book chapters, and 04 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

Experience

  • July 2016 - Present:
    Assistant Professor (Pharmaceutics), NIPER-Ahmedabad (India)
  • Aug 2014-May 2016:
    Lecturer in Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur (KL), Malaysia
  • Aug 2013 - Jun 2014:
    Postdoctoral Fellow-II, , University of Texas, UT Southwestern Medical Centre, Dallas, USA
  • Jul 2011 – Aug 2013:
    Postdoctoral Fellow-I, University of Hawaii, College of Pharmacy, Hilo, Hawaii, USA
  • Mar 2008 – Jun 2011:
    Senior Research Fellow (SRF-CSIR), Awarded by Council of Scientific & Industrial Research (CSIR), New Delhi, India for pursuing Ph. D, availed at Dr. Hari Singh Gour Central University, Sagar, India
  • Aug 2009 – Aug 2010 :
    Commonwealth Fellow, University of Central Lancashire, Preston, UK
  • Apr 2009 :
    National Doctoral Fellow, All India Council of Technical Education (AICTE), New Delhi, India
  • Sep 2007 – Mar 2008 :
    Scientist (F & D), Ranbaxy Pharmaceuticals ltd, Dewas, India
  • Jul 2006 – Sep 2007 :
    Lecturer of Pharmaceutics,BITS College of Pharmacy, Bhopal, India
  • 2004-2006 :
    Junior Research Fellow (JRF-AICTE),Awarded by All India Council of Technical Education (AICTE), New Delhi, India for pursuing M. Pharm, availed at Dr. Hari Singh Gour Central University, Sagar, India

Honors/Awards/Grants/Consultancies

Honours

  • Guest Editor in chief ‘Thematic’: Current Pharmaceutical Design (Bentham Publisher), Impact factor: 3.3 (Currently serving)
  • INTERNATIONAL ADVISORY BOARD MEMBERS, International Journal Of Pharmaceutical Sciences And Research. (2008-Till Date)
  • Executive board Member: Int. J. Pharm. Pharma. Sci. (2009-Till Date)
  • Assistant editor: American Journal of Phytomedicine and Clinical Therapeutics (2012-Till date); http://www.ajpct.org/index.php/editorial-board
  • Editorial Advisory Board, Pharm Aspire Journal
  • Editorial Board Member, American Journal of Pharmaceutical Sciences and Nanotechnology
  • Editorial Panel Member, EC Pharmacology and Toxicology https://www.ecronicon.com/ECPT-EB.php
  • REVIEWER FOR SCIENTIFIC JOURNAL
  • Chemical Reviews (ACS), Molecular Pharmaceutics (ACS), Drug Discovery Today, Current Nanoscience, J Drug Targeting (Informa), Asian J. Pharm Sci.,J. of Biomedical Nanotechnology; Current Drug Delivery, Int. J. Pharmaceutical Sciences, J. Biomedical Research, Physica E, Science of Advanced Material, Biomedical Research International, Drug Development and Industrial Pharmacy.

Awards

  • Best Poster Award -2014: Royal Chemical Society, UK-Malaysia Joint Conference, Malaysia
  • Research Travel Award, Society of Nuclear Medicine Conference, The University of Texas- USA- 2014,Awarded to selected applicants by significance of work by UTSW panel-USA
  • IRISH Research Council Government Postdoctoral Award- 2013, One of most competitive fellowship awarded by Govt. of Ireland
  • Travel Grant, Controlled Release Society Conference- The University of Hawaii, USA- 2013,Awarded to selected postdoctoral fellows by Hawaiian CRS Chapter-USA
  • Young Scientist Award- 2012: 1st International Conference on Pharmacy and Pharmaceutical Sciences, Bhopal-India
  • Commonwealth Fellowship, British Council-London, UK- 2008-2009, Awarded to 4 Pharmacists from India to pursue Ph.D. work in UK
  • Travel Grant, Int. Conference on Biomedical Application of Dendrimer, France- 2009, Awarded by University of Central Lancashire, UK to present research work
  • Senior Research Fellowship, Council for Scientific and Industrial Research, New Delhi, India- 2008-2012, One of India’s most prestigious scholarship (Funded for Ph.D. research work)
  • Best paper award,Mottan Devi Dandiya Trust, India, Awarded for publication in Chemical Reviews 2009-2010 (Impact factor-44.66)
  • National Doctoral Fellowship, All India Council of Technical Education, New Delhi, India, declined- 2009, One of India’s most prestigious scholarship
  • Junior Research Fellow (M. Pharm),All India Council of Technical Education, New Delhi, India, 2004-2006

Grants

  • Aptamer-targeted dendronized polymeric nanoparticles to deliver Anti-miRNA fortreatment of Triple Negative Breast Cancer, 50 Lakh, DST, SERB India- 2017, Ongoing, Role: PI
  • Triple punch approach for triple negative breast cancer by delivering siRNA anddoxorubicin using graphene oxide wrapped polymeric nanoparticles, 20 Lakh, DST, SERB India- 2017, Ongoing, Role: Primary Supervisor
  • A novel strategy to explore endosomal degradation of gene therapeutics, 133,000 Malaysian RM(22 Lakh INR) Fundamental Research Grant Scheme, Ministry of Health, Malaysia, 2016, Ongoing, Role: PI
  • Synthesis and characterization of MTX conjugated gold nanocapsules for cancer Therapy, 12,000 Malaysian RM (2 Lakh INR) IMU-JC, Graduate Research Grant, Kuala Lumpur- Malaysia- 2015, Completed, Role: PI
  • Formulation Development And Evaluation Of Aloe Vera/gold loaded Alginate-Gelatin Composite Film For Wound Healing Activity, 12,000 Malaysian RM, (2 Lakh INR) IMU-JC, Graduate Research Grant, Kuala Lumpur- Malaysia-2015, Completed, Role: Co-PI
  • Anticancer activity of hybrid silver-graphene oxide nanocomposites, 12,000 Malaysian RM (2 Lakh INR) IMU-JC, Graduate Research Grant, Kuala Lumpur- Malaysia, 2015, Completed, Role: Co-PI
  • To evaluate anti-proliferative potential of dendrimer stabilized lipid vesicular packets of paclitaxel against Lung Cancer cell lines 3,000 Malaysian RM (50000 INR) Biomed Research Grant, IMU, Kuala Lumpur, Malaysia-2014, Completed, Role: PI
  • To evaluate anti-proliferative activity of andrographolide microemulsion in cancer cell lines, 3,000 Malaysian RM (50000 INR) Biomed RES Grant, IMU, Kuala Lumpur, Malaysia, 2014, Completed, Role: Co-PI
  • Development of Gold nanoprobe for imaging and therapy for prostate cancer, 45,500 US $, University of Texas, UT Southwestern, Medical Centre- Dallas, USA, 2014, Completed, Role: PI
  • Development of Hybrid Nanocarrier for Mesothelioma Therapy, 44,000 US $, The University of Hawaii, Hilo, USA, 2013, Completed, Role: PI
  • Synthesis and evaluation of folate-targeted dendrimer as anti-cancer drug carrier, 21,000 GBP, Commonwealth Commission, London, UK, 2009, Completed, Role: PI
  • Formulation of dendrimer-based targeted anticancer formulation, 38,0,000 INR, Council for Scientific and Industrial Research, New Delhi, India, 2008, Completed, Role: PI
  • Investigation of receptor upregulation and cancer targeting strategy, 14,0,000 INR, All India Council for Technical Education, New Delhi, India, 2004, Completed, Role: PI

Consultancies

  • Industrial consultancy project for the development of sustained releasing formulation of natural extract, 70,000 Malaysian RM (12 Lakh INR) InQ Pharmaceuticals, Malaysia, 2015, Completed Role: Co-PI

Publications

  • Akshant Kumavat, Prachi Dapse, Narendra Kumar, Dinesh Mishra, Rahul Maheshwari, Pallab Bhattacharya, Tekade RK.(2018) Budding alliance of Nanotechnology in RNA interference therapeutics, Current Pharmaceutical Design. doi: 10.2174/1381612824666180807113948. (Accepted)
  • Keval Shah, Sunita Chawla, Anuradha Agrawal, Goutham Reddy, Rahul Maheshwari, Kiran Kalia, Tekade RK. (2018) Nanostructured Hyaluronic acid-based materials for the delivery of siRNA, Current Pharmaceutical Design. doi: 10.2174/1381612824666180807123705. (accepted)
  • Shubhangi Mahajana, Abhimanyu Patharkar, Kaushik Kuche, Rahul Maheshwari, Pran Kishore Deb, Kiran Kalia, Tekade RK. (2018) Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer, International Journal of Pharmaceutics.548(01), 540-558 https://doi.org/10.1016/j.ijpharm.2018.07.027
  • Hardi Jogi, Rahul Maheshwari, Nidhi Raval, Kaushik Kuche, Vishakha Tambe, Kit-Kay Mak, Mallikarjuna Rao Pichika, Tekade RK.(2018) Carbon nanotubes in the delivery of anticancer herbal drugs, Nanomedicine. 13(10), https://doi.org/10.2217/nnm-2017-0397
  • Bapi Goraina, Hira Choudhury, Manisha Pandey, Prashant Kesharwani, Muhammad Mustafa Abeer, Tekade RK, Zahid Hussain.(2018) Carbon nanotube scaffolds as emerging nanoplatform for myocardial tissue regeneration: A review of recent developments and therapeutic implications, Biomedicine & Pharmacotherapy. 104, 496–508. https://doi.org/10.1016/j.biopha.2018.05.066
  • Kaushik Kuche, Rahul Maheshwari, Vishakha Tambe, Kit-Kay Mak, Hardi Jogi, Nidhi Raval, Mallikarjuna Rao Pichika, Tekade RK.(2018) Carbon nanotubes (CNTs) based advanced dermal therapeutics: Current trends and future potential, RSC-Nanoscale. 19, 8911-8937. DOI: 1039/C8NR01383G,
  • Pinaki Sengupta, Bappaditya Chatterjee and Tekade RK. (2018) Current regulatory requirements and practical approaches for stability analysis of pharmaceutical products: A comprehensive review, International Journal of Pharmaceutics. 543 (1-2), 328-344. DOI:https://doi.org/10.1016/j.2018.04.007.
  • Dnyaneshwar Kalyane, Rahul Maheshwari., Tekade RK , Kiran Kalia.(2018) Nanotechnology-based precision tools for the targeted therapy of triple negative breast cancer. Journal of Cell and Tissue Research Vol. 18(1) 6335-6343
  • Mohammed Al-Qattan, Pran KishoreDeb, Tekade RK. (2018) Molecular dynamics simulation strategies for designing carbon-nanotube-based targeted drug delivery. Drug Discovery Today,23(2), 235-250. https://doi.org/10.1016/j.drudis.2017.10.002
  • Tekade RK,Vijayarajkumar P, Jain NK, Dendrimers in oncology: An expanding horizon. Chemical Reviews (ACS) (2009), 109, 49-87 (Impact Factor: 45.66).
  • Tekade RK*, Sun X. The Warburg effect and glucose-derived cancer theranostics. Drug Discov Today. 2017 Aug 24. pii: S1359-6446(17)30416-6(Impact Factor- 6.36).
  • Tekade RK*, Tekade M, Kesharwani P. RNAi combined Nano Chemotherapeutics to tackle Resistant Tumors, Drug Discovery Today 2016, pii: S1359-6446(16)30247-1. In press,DOI: 10.1016/j.drudis.2016.06.029. PMID: 27380716(Impact Factor- 5.96).
  • Tekade RK,Youngren-Ortiz SR, Yang H, Haware R, Chougule MB. Designing hybrid onconase nanocarriers for mesothelioma therapy: a taguchi orthogonal array and multivariate component driven analysis.Molecular Pharmaceutics 2014, 11, 3671-83. DOI: 10.1021/mp500403b. PMID: 25179221 (Impact Factor- 4.78).
  • Kesharwani P, Tekade RK,Jain NKGeneration dependent cancer targeting potential of poly (propyleneimine) dendrimer. Biomaterials 2014, 35, 5539-48. 2014 DOI: 10.1016/j.biomaterials.2014.03.064. PMID: 24731713(Impact Factor- 8.3).
  • Lalu L, Tambe V, Pradhan D. Tekade RK*. Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions. Journal of Controlled Release (2017) pii: S0168-3659(17)30745-9(Impact Factor- 7.78).
  • Gandhi NS, Tekade RK,Chougule MB. Nanocarrier mediated delivery of sirna/mirna in combination with chemotherapeutic agents for cancer therapy: current progress and advances. Journal of Controlled Release. 2014, 194, 238-256 DOI: 10.1016/j.jconrel.2014.09.001. PMID: 25204288 (Impact Factor- 7.26).
  • Ghanghoria R, Kesharwani P, Tekade RK*, Jain NK. Targeting luteinizing hormone-releasing hormone: A potential therapeutics to treat gynecological and other cancers. J Control Release. 2016, pii: S0168-3659(16)31169-5. doi: 10.1016/j.jconrel.2016.11.002. [Epub ahead of print] PMID: 27840168. (Impact Factor- 7.26).
  • Ghanghoria R, Tekade RK*, Mishra AK, Chuttani K, Jain NK. Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel. Nanomedicine (Lond). 2016, 11(7):797-816. DOI: 10.2217/nnm.16.19. PMID: 26980704 (Impact Factor- 5.4).
  • Moeendarbari S, Tekade RK, Mulgaonkar A, Christensen P, et al. Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors. Nature Scientific reports, 2016, 6, 20614. DOI:10.1038/srep20614 (Impact Factor- 5.578).
Complete list

Book/Book Chapter/Patents/Peer Review- Abstract

Book Chapters

  • Jain NKand Tekade RK "Drug delivery strategies for poorly water–soluble drugs” 2012, Wiley blackwell publisher, Kent, U.K. pp: 373-399. (ISBN: 978-0-470-71197-2)
  • Chougule M, Tekade RK, Hoffmann PR, et al. Nanomaterial basedgene and drug delivery: pulmonary toxicity considerations, Bio-interactions of nano materials, 2014, Taylor and Francis,Boca Raton, Florida, USA, ISBN 9781466582385
  • Tekade RK*,Tekade M. Ocular Bioadhesives and Their Applications in Ophthalmic Drug Delivery, in Nano-Biomaterials For Ophthalmic Drug Delivery, Springer, Switzerland, 2016, pp 211-230. DOI 10.1007/978-3-319-29346-2_10.
  • Tekade RK, Nanotechnology in development of nanomedicines, Elsevier-USA, 2016, In press
  • Tekade RK, Carbon nanotubes in targeting and delivery of drugs, Elsevier, USA, 2016, In press
  • Tekade RK, Chougule, M, Solid Lipid Nanoparticles for Targeting and Delivery of Drugs and Genes, Elsevier, USA, 2016, In press
  • Tekade RK, Soni N. Et al. Omics driven novel technologies in food and nutrition research CRS Press, Boca Raton, Florida, USA, 2016, In press
  • Tekade RK, Soni N. et al.Phaecogenomics and Pharmacoepigenomics: Impact on Therapeutic Strategies, Springer publisher, 2016, In press
  • Tekade RK., Natural ingredients/botanical extracts for nutraceutical industry, Taylor and Francis (CRC), Boca Raton, Florida, USA, 2017, accepted
  • Tekade RK, Chapter-5 Fabrication of mucoadhesive-dendrimers as solid dosage forms, Elsevier, Accepted.
  • Tekade RK., Chapter-1: Dendrimers in Targeted Drug Delivery; In "Dendrimers for Drug Delivery” Apple Academic Press, Ontario, Canada; 2017
  • Tekade RK., Chapter-5: "Dendrimers in Gene Delivery”; In "Dendrimers for Drug Delivery” Apple Academic Press, Ontario, Canada; 2017
  • Tekade RK., Chapter-13: "An Overview of Dendrimers and Its BiomedicalApplications”; In "Dendrimers for Drug Delivery” Apple Academic Press, Ontario, Canada; 2017

Patent

  • Ultradeformable liposomal gel of Vancomycin. Indian patent Application Number: 1045/MUM/2015
Presentations:
National : 10
International: 15
Projects:
Completed 11
Ongoing 03
Ph. D
Completed 02
Ongoing 03
MS Dissertation:
Completed: 08
Ongoing: 08
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