Research

Thrust areas: Diabetes and Obesity, Infectious diseases, Cancer, Cardiovascular diseases and Neuronal disorders

Diabetes and Obesity:

  • Proteomics and genomics biomarkers for diabetes and its microvascular complications
  • Lead based design and development of NCEs of natural pharmacophores as anti-diabetic and anti-obesity leads
  • Stabilized lipid vesicular formulation for oral delivery of therapeutic proteins and peptides (Insulin and peptidic incretin hormones such as GLP-1, exendin-4)
  • PK-PD herb-drug interaction studies for therapeutic modulation in diabetes

Infectious diseases:

  • Novel and targeted drug delivery systems such as dissolvable biodegradable polymeric transdermal microneedle arrays for drug delivery in HIV infections
  • Translingual formulation for treatment against onycomychosis infection
  • Design and synthesis of small molecule heterocycles targeting redox machinery of infectious bacteria
  • Target Oriented Synthesis (TOS) based development of New Chemical Entities (NCEs) of natural scaffolds against Multi Drug Resistant Tuberculosis and its secondary complications
  • Diversity Oriented Synthesis (DOS) of small molecules as anti-HIV leads

Cancer:

  • SNPs and its role in oral cancer in Western Indian population
  • Structure-based drug design, synthesis and screening of small molecules, including pro-apoptotic BAX activators
  • Thiazole heterocyclic chemical probes and their screening for lung cancer
  • Stabilized lipid vesicular formulation for oral delivery of therapeutic proteins and peptides (Buserelin, Abarelix) for prostate cancer and uterine cancer
  • Exploring marine algae in search of new leads for treatment of breast cancer and lung cancer
  • Cancer stem cell (CSC) re-differentiation, regime for prevention of relapse
  • Discovery of new natural products as leads for lung cancer

Cardiovascular diseases:

  • Novel and targeted drug delivery systems for angina
  • Development of tri-layered tablet formulation for controlled delivery of antihypertensives
  • Development of bio-degradable stents and coatings

Neuronal disorders:

  • Role of JAK pathway Alzheimer’s disease
  • Modulation of microgilal phenotype in neuroinflammation in cerebral ischemia
  • Melatonin in traumatic brain injury
  • Discovery of new natural products as neuroprotective leads

Other areas:

  • Cartilage regeneration by using biodegradable nano-fibre scaffolds
  • Osteoconductive coatings for orthopaedic implants
  • Bioactive bone grafts for bone regeneration
  • Induced pluripotent stem cells
The dedicated faculty at NIPER-G investigates different aspects of human health such as diabetes, tuberculosis, obesity, cancer, neurologic disorders. Research is being conducted across the spectrum
  • Proteomics and genomic biomarkers, pharmacogenomics and stem cell research
  • Drug discovery and development using molecular modeling
  • Drug discovery from natural sources
  • Targeted drug delivery system, solid state characterization, QbD in formulation
  • Analytical/bioanalytical method development and impurity profiling
  • Development of biomaterial for cardiovascular, orthopedic and ocular implants
  • Metal toxicology, neurodegeneration, Cognition
We believe in exploring multidisciplinary research in all departments and help the student to excel in their field and develop the skills. NIPER has been actively pursuing the research in different departments

Research Projects

On Going

Project Title Principal Investigator Sponsoring Agency Year
Exploring the molecular mechanism of butter oil enriched nanoformulation in enhancing nasal to brain delivery and its potential role in promoting neurogenesis PI: Dr.Manju Mishra, Co PI:Dr. Pallab Bhattacharya DST SERB 2017-2020
Bioprospecting endolichenicfungi from Mangroves in Negombo lagoon in Sri Lanka and Gulf of Khambat, Gulf of Kutch from Gujarat India; An untapped treasure trove for discovery of special structures and bioactive compounds
(Grant No: DST/INT/SL/P-22/2016)
Prof. Kiran Kalia Sri Lankan Partner: Prof. Priyali Pranagama University of Kelniya, Sri Lanka DST, Indo Sri Lanka Joint Research Program 2017-2020
Bio-engineered three-dimensional stem cell niche for intervertebral Disc repair and regeneration Dr.Akshay Srivastava DST SERB 2017-2020
Regulatory non-coding RNA mediated mesenchymal stem cell engineering: A safety and efficacy study in rodent model of ischemic stroke Dr.Pallab Bhattacharya DST SERB 2017-2020
Mitochondrial protection in ischemic stroke by using microRNA mediated engineered stem cells. Dr.Pallab Bhattacharya ISN,USA 2017-2020
Dissecting Brain Reward Circuitry & CNS Comorbidities in Chronic Neuropathic Pain . Dr.Vinod Tiwari DST SERB 2017-2020
Aptamer targeted dendronized polymeric nanoparticles to deliver Anti-miRNA for treatment of Triple Negative Breast Cancer Dr Rakesh Tekade DST, SERB India 2017-2020
Triple punch approach for triple negative breast cancer by delivering siRNA and doxorubicin using graphene oxide wrapped polymeric nanoparticles Dr Rakesh Tekade DST, SERB India 2017-2020
A novel strategy to explore endosomal degradation of gene therapeutics Dr Rakesh Tekade Fundamental Research Grant Scheme, Ministry of Health, Malaysia. 2016-2018
Synthesis and development of antitubercular 1,4-naphthoquinone congeners asMycobacterium tuberculosis methionine aminopeptidases inhibitors Dr. Anita Mahapatra
Dr. Neelam Chauhan (Co-PI)
DBT 2013-2016
In-situ gelling mucoadhesive system for brain delivery of p-Glycoprotein (P-gp) substrates via nasal route: Effect of a novel lipidic agent on drug release and P-gp inhibition Dr. Manju Misra DST, INSPIRE 2012-2017

Completed

Project Title Principal Investigator Sponsoring Agency Year
Design of Oral delivery system for macromolecules using gastrointestinal patch system: Role of fatty acid as penetration enhancer Dr. Manju Misra DBT, RGYI 2012-2015
A non-viral vector for inducing pluripotency Dr. Neelam Chauhan DBT, RGYI 2010-2012
A non-viral vector for inducing pluripotency Dr. Neelam Chauhan GSBTM 2010-2012
Biotech pharma link unit for converting biological therapeutics into dosage forms for SMEs Dr. Neelam Chauhan (Co-PI) IC, Govt. of Gujarat 2009-2011
Centre of Excellence for Quality Assurance of Drugs Dr. Anita Mahapatra IC, Govt. of Gujarat 2009-2011

Patents

  • Govinda Kapusetti, Jaicy Jacob, Kiran Kalia. Cartilage Regeneration Using Piezoelectric Based Scaffold. Indian Patent File No. 201621008797.
  • Neelam Chauhan, Shaishavi Jansari, Kiran Kalia. Minicircle DNA vector for inducing pluripotency in nucleated blood cells and other cell types and its re-differentiation for use in regenerative medicine. Indian Patent File No. 201621031592.
  • Vinod Jairaj, Satyendra Kumar, Kiran Kalia. Process of isolation and purification of Swertiamarin from Enicostemme littorale. Indian Patent File No. 201621008411

Publications

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