Rakesh Kumar Tekade, Ph. D

PDF: UT Southwestern Medical Centre, Dallas, Texas, USA

PDF: University of Hawaii, Hilo, Hawaii, USA

Commonwealth Split Site Ph. D Fellow :University of Central Lancashire, Preston, UK (2009)

Ph.D: Dr Hari Singh Gour Central University, Sagar, India (2011)


Rakesh Kumar Tekade, Ph. D

Assistant Professor

Tele: +91 79 66745555

E-mail :rakeshtekade@gmail.com, rakeshtekade@niperahm.ac.in

Research Interest

Dr. Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, is an academic-researcher with >10 year of teaching and research and postdoctoral experience gained in USA, UK, Malaysia, and India. He is recipient of several acclaimed awards including Commonwealth Fellow- UK, AICTE-National Doctoral Fellowship, IRISH-Postdoctoral Award, CSIR-SRF, AICTE-JRF. He has taken two postdoctoral Fellowships from University of Hawaii, USA and UT Southwestern Medical Centre, USA.

Dr. Tekade’s research group at NIPER-A investigates the design, development, and characterization of targeted nanotechnology-based formulations for the site-specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins, and peptides for the treatment of cancer. Development of NIR-Laser activatable Nanoseeds for the treatment of cancer as well as for the prevention of post-surgical relapse of the resectable tumor is another thurst goal of his research focus. An overarching goal of his current research interests encompass development of novel polymeric nanomaterial for effective cytosolic delivery of gene therapeutics. Dr. Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. His research group has also investigated the anticancer activity, Pharmacokinetics, pharmacodynamics, and molecular dynamics of several compounds and nanoformulations against cancer cell lines and tumorogenic mouse models. Till date, he has published > 100 peer reviewed publications in international SCI cited journals (>3800 citations; H–index of 33; cumulative Impact Factor: 395.10), contributed > 90 international reference book chapters (Elsevier, Springer, Taylor & Francis and Wiley), 05 invited editorial articles and 05 patent applications. He has delivered several invited researches talks and presented research finding in more than 30 scientific conferences. Till date he has mentored: 01 Postdoc, 04 Ph. D, 24 Masters, 10 B. Pharm/ Biomedical Science students.Dr. Tekade is an Editor in Chief of a famous Book Series entitled "Advances in Pharmaceutical Product Development and Research Series”. As an editor, he has published Five widely referred books namely: (i) Dosage Form Design Parameters, (ii) Dosage form Design Considerations, (iii) Fundamentals of Drug Delivery, (iv) Biomaterials and Bionanotechnology, and (v) Drug Delivery Systems. https://www.elsevier.com/catalog/pharma/pharmaceutical-science/drug-delivery/advances-in-pharmaceutical-product-development-and-research. He is expert reviewer for more than 50 peer reviewed international Journals of repute.

Experience

  • July 2016 - Present:
    Assistant Professor (Pharmaceutics), NIPER-Ahmedabad (India)
  • Aug 2014-May 2016:
    Lecturer in Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur (KL), Malaysia
  • Aug 2013 - Jun 2014:
    Postdoctoral Fellow-II ,, University of Texas, UT Southwestern Medical Centre, Dallas, USA
  • Jul 2011 – Aug 2013:
    Postdoctoral Fellow-I, University of Hawaii, College of Pharmacy, Hilo, Hawaii, USA
  • Mar 2008 – Jun 2011:
    Senior Research Fellow (SRF-CSIR), Awarded by Council of Scientific & Industrial Research (CSIR), New Delhi, India for pursuing Ph. D, availed at Dr. Hari Singh Gour Central University, Sagar, India
  • Aug 2009 – Aug 2010 :
    Commonwealth Fellow, University of Central Lancashire, Preston, UK
  • Apr 2009 :
    National Doctoral Fellow, All India Council of Technical Education (AICTE), New Delhi, India
  • Sep 2007 – Mar 2008 :
    Scientist (F & D), Ranbaxy Pharmaceuticals ltd, Dewas, India
  • Jul 2006 – Sep 2007 :
    Lecturer of Pharmaceutics ,BITS College of Pharmacy, Bhopal, India
  • 2004-2006 :
    Junior Research Fellow (JRF-AICTE ) ,Awarded by All India Council of Technical Education (AICTE), New Delhi, India for pursuing M. Pharm, availed at Dr. Hari Singh Gour Central University, Sagar, India

Honors/Awards/Grants/Consultancies

Honours

  • Nominated Member, Board of Studies, Gujarat Forensic State University, Department of Forensic Pharmacy, Gujarat.
  • rant reviewer for the FONDECYT FUNDS (Chile), National Science Centre (Poland); French National Research Agency (ANR) France, Khwarizmi International Award (KIA) (Iran).
  • Member- Board of Studies and Research (NIPER-A), Member- Research advisory committee (NIPER-A), Member- Equipment purchase committee (NIPER-A), Senate Member (NIPER-A), Member- Placement Cell (NIPER-A)
  • Guest Editor in chief ‘Thematic’: Current Pharmaceutical Design (Bentham Publisher), Impact factor: 3.3 (Currently serving)
  • INTERNATIONAL ADVISORY BOARD MEMBERS, International Journal Of Pharmaceutical Sciences And Research. (2008-Till Date)
  • Executive board Member: Int. J. Pharm. Pharma. Sci. (2009-Till Date)
  • Assistant editor: American Journal of Phytomedicine and Clinical Therapeutics (2012-Till date); http://www.ajpct.org/index.php/editorial-board
  • Editorial Advisory Board, Pharm Aspire Journal
  • Editorial Board Member, American Journal of Pharmaceutical Sciences and Nanotechnology
  • Editorial Panel Member, EC Pharmacology and Toxicology https://www.ecronicon.com/ECPT-EB.php
  • EXPERT REVIEWER FOR SCIENTIFIC JOURNAL
  • Chemical Reviews (ACS; IF- 52.5), J. Controlled Release (Elsevier; IF-7.8), Biomaterials (Elsevier; 8.4), Drug Discovery Today (Elsevier: IF-7.1), Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier; IF-5.8), Nanomedicine London (Future Medicine; IF-4.8), Biomaterial Science (Springer; IF-4.8), Molecular Pharmaceutics (ACS; 4.5), European J. Pharmaceutical Sciences (Elsevier; IF-4.5), J. Biomedical Nanotechnology (American Scientific Publishers; 4.5), Bioorganic Chemistry (Elsevier; IF-3.9), International Journal of Pharmaceutics (Elsevier; IF-3.7) to name the few

Awards

  • Best Poster Award -2014: Royal Chemical Society, UK-Malaysia Joint Conference, Malaysia
  • Research Travel Award, Society of Nuclear Medicine Conference, The University of Texas- USA- 2014 ,Awarded to selected applicants by significance of work by UTSW panel-USA
  • IRISH Research Council Government Postdoctoral Award- 2013, One of most competitive fellowship awarded by Govt. of Ireland
  • Travel Grant, Controlled Release Society Conference- The University of Hawaii, USA- 2013 ,Awarded to selected postdoctoral fellows by Hawaiian CRS Chapter-USA
  • Young Scientist Award- 2012: 1st International Conference on Pharmacy and Pharmaceutical Sciences, Bhopal-India
  • Commonwealth Fellowship, British Council-London, UK- 2008-2009, Awarded to 4 Pharmacists from India to pursue Ph.D. work in UK
  • Travel Grant, Int. Conference on Biomedical Application of Dendrimer, France- 2009, Awarded by University of Central Lancashire, UK to present research work
  • Senior Research Fellowship, Council for Scientific and Industrial Research, New Delhi, India- 2008-2012, One of India’s most prestigious scholarship (Funded for Ph.D. research work)
  • Best paper award ,Mottan Devi Dandiya Trust, India, Awarded for publication in Chemical Reviews 2009-2010 (Impact factor-44.66)
  • National Doctoral Fellowship, All India Council of Technical Education, New Delhi, India, declined- 2009, One of India’s most prestigious scholarship
  • Junior Research Fellow (M. Pharm ) ,All India Council of Technical Education, New Delhi, India, 2004-2006

Grants

  • Aptamer-targeted dendronized polymeric nanoparticles to deliver Anti-miRNA fortreatment of Triple Negative Breast Cancer, 50 Lakh, DST, SERB India- 2017, Ongoing, Role: PI
  • Triple punch approach for triple negative breast cancer by delivering siRNA anddoxorubicin using graphene oxide wrapped polymeric nanoparticles, 20 Lakh, DST, SERB India- 2017, Ongoing, Role: Primary Supervisor
  • A novel strategy to explore endosomal degradation of gene therapeutics, 133,000 Malaysian RM(22 Lakh INR) Fundamental Research Grant Scheme, Ministry of Health, Malaysia, 2016, Ongoing, Role: PI
  • Synthesis and characterization of MTX conjugated gold nanocapsules for cancer Therapy, 12,000 Malaysian RM (2 Lakh INR) IMU-JC, Graduate Research Grant, Kuala Lumpur- Malaysia- 2015, Completed, Role: PI
  • Formulation Development And Evaluation Of Aloe Vera/gold loaded Alginate-Gelatin Composite Film For Wound Healing Activity, 12,000 Malaysian RM, (2 Lakh INR) IMU-JC, Graduate Research Grant, Kuala Lumpur- Malaysia-2015, Completed, Role: Co-PI
  • Anticancer activity of hybrid silver-graphene oxide nanocomposites, 12,000 Malaysian RM (2 Lakh INR) IMU-JC, Graduate Research Grant, Kuala Lumpur- Malaysia, 2015, Completed, Role: Co-PI
  • To evaluate anti-proliferative potential of dendrimer stabilized lipid vesicular packets of paclitaxel against Lung Cancer cell lines 3,000 Malaysian RM (50000 INR) Biomed Research Grant, IMU, Kuala Lumpur, Malaysia-2014, Completed, Role: PI
  • To evaluate anti-proliferative activity of andrographolide microemulsion in cancer cell lines, 3,000 Malaysian RM (50000 INR) Biomed RES Grant, IMU, Kuala Lumpur, Malaysia, 2014, Completed, Role: Co-PI
  • Development of Gold nanoprobe for imaging and therapy for prostate cancer, 45,500 US $, University of Texas, UT Southwestern, Medical Centre- Dallas, USA, 2014, Completed, Role: PI
  • Development of Hybrid Nanocarrier for Mesothelioma Therapy, 44,000 US $, The University of Hawaii, Hilo, USA, 2013, Completed, Role: PI
  • Synthesis and evaluation of folate-targeted dendrimer as anti-cancer drug carrier, 21,000 GBP, Commonwealth Commission, London, UK, 2009, Completed, Role: PI
  • Formulation of dendrimer-based targeted anticancer formulation, 38,0,000 INR, Council for Scientific and Industrial Research, New Delhi, India, 2008, Completed, Role: PI
  • Investigation of receptor upregulation and cancer targeting strategy, 14,0,000 INR, All India Council for Technical Education, New Delhi, India, 2004, Completed, Role: PI

Consultancies

  • Industrial consultancy project for the development of sustained releasing formulation of natural extract, 70,000 Malaysian RM (12 Lakh INR) InQ Pharmaceuticals, Malaysia, 2015, Completed Role: Co-PI

Publications

  • Saraf J, Kalia K, Bhattacharya P, Tekade RK * , Growing Synergy of Nanodiamonds in Neurodegenerative Interventions, Drug Discovery Today, 2019, 24, 584-594. Doi: 10.1016/j.drudis.2018.10.012 ( IF: 6.36).
  • Pandey PK, Maheshwari R, Raval N, Gondaliya P, Kalia K, Tekade RK * . Nanogold-core multifunctional dendrimer for pulsatile chemo-, photothermal- and photodynamic- therapy of rheumatoid arthritis. J Colloid Interface Sci. 2019, 22, 544:61-77. Doi: 10.1016/j.jcis.2019.02.073 ( IF: 5.1).
  • Kalyane D, Raval N, Maheshwari R, Tambe V, Kalia K, Tekade RK * . Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer. Mater Sci Eng C Mater Biol Appl. 2019, 98, 1252-1276. Doi: 10.1016/j.msec.2019.01.066 ( IF: 5.091).
  • Muniswamy JJ, Raval N, Kiran Kalia, Tekade RK*.'Dendrimer-Cationized-Albumin’ Encrusted polymeric nanoparticle Improves BBB Penetration and Anticancer Activity of Doxorubicin, International J. Pharmaceutics, 2019, 15, 77-99. doi: 10.1016/j.ijpharm.2018.11.035 ( IF: 3.89).
  • Kuche M, Tambe V, Jogi H, Maheshwari R, Raval R, Kalia K, Tekade RK * . Carbon nanotubes based advanced dermal therapeutics: Current trends and future potential, RSC-Nanoscale, 2018,10, 8911-8937. DOI: 10.1039/c8nr01383g (IF: 7.36).
  • Ghanghoria R, Kesharwani P, Tekade RK * , Jain NK. Targeting luteinizing hormone-releasing hormone: A potential therapeutics to treat gynecological and other cancers. J. Controlled Release, 2018, 10, 277-301. DOI: 10.1016/j.jconrel.2016.11.002 (IF- 7.26).
  • Jogi H, Maheshwari R, Raval N, Kuche K, Tambe V, Tekade RK * . Carbon nanotubes in the delivery of anticancer herbal drugs, Nanomedicine (London) 2018, 15, 1187-1220. DOI: 10.2217/nnm-2017-0397 (IF: 4.81).
  • Mahajan S, Patharkar A, Kuche K, Maheshwari R, Deb PK, Kalia K, Tekade RK , Functionalized carbon nanotubes as emerging delivery system for the treatment of cancer, International J. Pharmaceutics 2018, 5, 540-558. DOI: 10.1016/j.ijpharm.2018.07.027 (IF- 3.89).
  • Sengupta P, Chatterjee B, Tekade RK . Current regulatory requirements and practical approaches for stability analysis of pharmaceutical products: A comprehensive review. International J. Pharmaceutics 2018, 543, 328-344. DOI: 10.1016/j.ijpharm.2018.04.007 ( IF: 3.69).
  • Kumavat A, Dapse P, Kumar N, Mishra D, Maheshwari R, Bhattacharya P, Tekade RK * , Budding alliance of Nanotechnology in RNA interference therapeutics, Current Pharmaceutical Design, 2018 [Ahead of print] DOI: 10.2174/1381612824666180807113948 (IF- 3.35).
  • Shah K, Chawla S, Agrawal A, Reddy G, Maheshwari R, Kalia K, Tekade RK * . Nanostructured Hyaluronic acid-based materials for the delivery of siRNA. Current Pharmaceutical Design, 2018 [Ahead of print]. DOI: 10.2174/1381612824666180807123705 (IF- 3.35).
  • Gorain B, Choudhury H, Pandey M, Kesharwani P, Abeer MM, Tekade RK , Carbon nanotube scaffolds as emerging nanoplatform for myocardial tissue regeneration: A review of recent developments and therapeutic implications. Biomed Pharmacother. 2018, 104, 496-508. DOI: 10.1016/j.biopha.2018.05.066 ( IF: 2.83).
  • Lalu L, Tambe V, Pradhan D. Tekade RK * . Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions. J. Controlled Release, 2017, 268, 19-39. DOI: 10.1016/j.jconrel.2017.07.035 ( IF: 7.78).
Complete list

Book/Book Chapter/Patents/Peer Review- Abstract

Book

  • Tekade RK (Editor), DOSAGE FORM DESIGN CONSIDERATIONS, Volume -I, Publisher: ELSEVIER, ISBN: 978-0-12-814423-7, Place of Publication: USA .ONLINE LINK: https://www.elsevier.com/books/dosage-form-design-considerations/tekade/978-0-12-814423-7
  • Tekade RK (Editor), DOSAGE FORM DESIGN PARAMETERS, Volume – II, Publisher: ELSEVIER, ISBN: 9780128144213, Place of Publication: USA.ONLINE LINK: https://www.elsevier.com/books/dosage-form-design-parameters/tekade/978-0-12-814421-3
  • Tekade RK (Editor), Basic Fundamentals of Drug Delivery, Publisher: ELSEVIER, ISBN: 78-0-12-817909-3, Place of Publication: USA.ONLINE LINK: https://www.elsevier.com/books/basic-fundamentals-of-drug-delivery/tekade/978-0-12-817909-3
  • Tekade RK (Editor), Biomaterials and Bio-Nanotechnology, Publisher: ELSEVIER, ISBN: 978-0-12-814427-5, Place of Publication: USA.ONLINE LINK: https://www.elsevier.com/books/biomaterials-and-bio-nanotechnology/tekade/978-0-12-814427-5
  • Tekade RK (Editor), Drug Delivery Systems, Publisher: ELSEVIER, ISBN: 978-0128144879, Place of Publication: USA .ONLINE LINK: https://www.elsevier.com/books/drug-delivery-systems/tekade/978-0-12-814487-9

Book Chapters

  • Jain NKand Tekade RK "Drug delivery strategies for poorly water–soluble drugs” 2012, Wiley blackwell publisher, Kent, U.K. pp: 373-399. (ISBN: 978-0-470-71197-2)
  • Chougule M, Tekade RK, Hoffmann PR, et al. Nanomaterial basedgene and drug delivery: pulmonary toxicity considerations, Bio-interactions of nano materials, 2014, Taylor and Francis ,Boca Raton, Florida, USA, ISBN 9781466582385
  • Tekade RK * ,Tekade M. Ocular Bioadhesives and Their Applications in Ophthalmic Drug Delivery, in Nano-Biomaterials For Ophthalmic Drug Delivery, Springer, Switzerland, 2016, pp 211-230. DOI 10.1007/978-3-319-29346-2_10.
  • Tekade RK, Nanotechnology in development of nanomedicines, Elsevier-USA, 2016, In press
  • Tekade RK, Carbon nanotubes in targeting and delivery of drugs, Elsevier, USA, 2016, In press
  • Tekade RK, Chougule, M, Solid Lipid Nanoparticles for Targeting and Delivery of Drugs and Genes, Elsevier, USA, 2016, In press
  • Tekade RK, Soni N. Et al. Omics driven novel technologies in food and nutrition research CRS Press, Boca Raton, Florida, USA, 2016, In press
  • Tekade RK, Soni N. et al.Phaecogenomics and Pharmacoepigenomics: Impact on Therapeutic Strategies, Springer publisher, 2016, In press
  • Tekade RK., Natural ingredients/botanical extracts for nutraceutical industry, Taylor and Francis (CRC), Boca Raton, Florida, USA, 2017, accepted
  • Tekade RK, Chapter-5 Fabrication of mucoadhesive-dendrimers as solid dosage forms, Elsevier, Accepted.
  • Tekade RK., Chapter-1: Dendrimers in Targeted Drug Delivery; In "Dendrimers for Drug Delivery” Apple Academic Press, Ontario, Canada; 2017
  • Tekade RK., Chapter-5: "Dendrimers in Gene Delivery”; In "Dendrimers for Drug Delivery” Apple Academic Press, Ontario, Canada; 2017
  • Tekade RK., Chapter-13: "An Overview of Dendrimers and Its BiomedicalApplications”; In "Dendrimers for Drug Delivery” Apple Academic Press, Ontario, Canada; 2017

Patent

  • Ultradeformable liposomal gel of Vancomycin. Indian patent Patent Application Number: 1045/MUM/2015. Inventor Name: Maheshwari RM, Yadav R,Tekade RK
  • Development of an advanced, "Mix-and-Deliver-Type” In Vivo applicable Polymeric Gene Transfecting Reagent for Cancer Therapy, Indian patent,Patent Application No: 201821043610 (Date: 20/11/2018). Inventor Name: Tekade RK, Tambe V, Gondaliya P, Kalia K
  • Targeting Peripheral Neurons using Tramadol hydrochloride encapsulated PEGylated albumin nanoparticles for safe and effective antinociceptive activity, Indian patent,application under filing. Inventor Name: Tekade RK, Tambe V, Gondaliya P, Kalia K
  • Method of loading and stabilization of siRNA in negatively charged Polymer for cytosolic delivery of same.Indian patent, application under filing. Inventor Name: Tekade RK, Rava N, Jogi H, Gondaliya P, Kalia K
Presentations:
National : 15
International: 17
Projects:
Completed 12
Ongoing 08
Ph. D
Completed 02
Ongoing 03
MS Dissertation:
Completed: 30
Ongoing: 08
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