Dr. Ravi Shah | Faculty | National Institute of Pharmaceutical Education & Research

Ph.D. NIPER SAS Nagar (Mohali), India, 2010

Dr. Ravi Shah

Associate Professor

Tele : 079-66745555

E-mail : ravi.shah@niperahm.ac.in,ravi.shah@niperahm.res.in

IRINS ProfileIRINS Profile

Research Interest

Development of analytical strategies for drug development and discovery with specific focus on:

Characterization of complex APIs and biosimilars
Characterization of complex formulations and sameness strategy development for regulatory submission
In-vitro release and its correlation with formulation strategies
Bioanalytical, biomarker analysis and metabolomics
LC-MS and NMR based characterization of impurities, drug-drug/ drug-excipient interaction products and degradation products
Pre-formulation assessment including polymorph characterization, salt screening, drug- excipient compatibility studies, rheological assessment, particle properties

Experience

February 2019 – Present:
Associate Professor, Department of Pharmaceutical Analysis, NIPER Ahmedabad, Gujarat, India.
August 2015 – February 2019
Principal Scientist, Associate Director- AR&D,Integrated Product Development Organization, Dr. Reddy’s Laboratory, Bangalore.
April 2015 - July 2015:
Senior Principal Investigator, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
May 2013 – March 2015:
Principal Investigator, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore.
April 2011 – April 2013:
Research Investigator, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore.
Octomber 2010 – March 2011:
Associate Scientific Manager, AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
July 2007 – September 2010:
PhD Scholar, Department of Pharmaceutical Analysis, NIPER-SAS Nagar, Mohali

Honours/Awards/Grants/Consultancies

Awards

PoC of the Year 2018, Dr. Reddy’s Laboratories.
Galaxy BMS Award, Biocon-Bristol Myers Squibb R&D Center.
Team Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
Individual Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
Golden R&D Star Award, Biocon-Bristol Myers Squibb R&D Center.
Team Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
Golden R&D Star Award, Biocon-Bristol Myers Squibb R&D Center.
AAPS Travel Award, American Association of Pharmaceutical Scientists.
Best Poster Presentation Award, Indian Pharmaceutical Congress.
Innocentive award with Cash prize of US $15000, Innocentive Inc.
Second prize in oral presentation, Indian Society for Mass Spectrometry.
DST Travel Award for presenting research work at British Pharmaceutical Conference.
Best Out-Going Student of the batch: B.Pharm 2001-2005 SGRS CoP, Pune University.
Merit Scholarship Award, Sir Ratan Tata Trust.

Publications

Kalyani Sharma, Harsh Thakkar, Nancy Goyal and Ravi P. Shah,. (2021). LC-HRMS Studies on Ruxolitinib Degradation: A Comprehensive Approach during Drug Development, Analytical Methods. doi.org/10.1039/D1AY01915E
Manish Kumar Sharma, Amit Kumar Sahu, Ravi P. Shah,, Pinaki Sengupta. (2021). A systematic UHPLC-Q-TOF-MS/MS based analytical approach for characterization of flibanserin metabolites and establishment of biotransformation pathway, Journal of Chromatography B. 123011, doi.org/10.1016/j.jchromb.2021.123011
Harsh Thakkar, Rameswari Eerla, Shriya Gangakhedkar, Ravi P. Shah. (2021). Exploring Unexplored Biomarkers of Oxidative Distress and their Use, Advances in Redox Research. 100020, https://doi.org/10.1016/j.arres.2021.100020
Sagar Salave, Sonali Jain, Ambika Chamoli, Amit Mandoli, R.P. Shah, Kiran Kalia, Derajram Benival. (2020). Role Of Biologicals For Combating Covid-19: A Systematic Review, World Journal Of Pharmacy And Pharmaceutical Sciences,9(12), 456-484. DOI: 10.20959/wjpps202012-17770
Manish Kumar Sharma, R.P. Shah,, Pinaki Sengupta. (2020). Amalgamation of Stress Degradation and Metabolite Profiling in Rat Urine and Feces for Characterization of Oxidative Metabolites of Flibanserin using UHPLC-Q-TOF-MS/MS, H/D Exchange and NMR Technique, Journal of Chromatography B. 121993. doi.org/10.1016/j.jchromb.2020.121993
R.P. Shah, A. Garg, S.P. Putlur, S. Wagh, V. Kumar, V. Rao, S. Singh, S. Mandlekar, S. Desikan, Practical and economical implementation of online H/D exchange in LC-MS., Anal. Chem. 85; 10904–10912. doi:10.1021/ac402339s.
R.P. Shah, V. Kumar, S. Singh, Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products., Rapid Commun. Mass Spectrom. 22; 613–22. doi:10.1002/rcm.3403.
R.P. Shah, A. Sahu, S. Singh, Identification and characterization of degradation products of irbesartan using LC-MS/TOF, MS(n), on-line H/D exchange and LC-NMR., J. Pharm. Biomed. Anal. 51; 1037–46. doi:10.1016/j.jpba.2009.11.008.
R.P. Shah, S. Singh, Identification and characterization of a photolytic degradation product of telmisartan using LC-MS/TOF, LC-MSn, LC-NMR and on-line H/D exchange mass studies., J. Pharm. Biomed. Anal. 53; 755–61. doi:10.1016/j.jpba.2010.05.005.
R.P. Shah, A. Sahu, S. Singh, LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: a comprehensive approach during drug development., Anal. Bioanal. Chem. 405; 3215–31. doi:10.1007/s00216-013-6760-1.
S. Singh, T. Handa, M. Narayanam, A. Sahu, M. Junwal, R.P. Shah, A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products, J. Pharm. Biomed. Anal. 69; 148–173. doi:10.1016/j.jpba.2012.03.044.
V. Kumar, R.P. Shah, S. Singh, LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products., J. Pharm. Biomed. Anal. 47; 508–15. doi:10.1016/j.jpba.2008.01.041.
S. Mehta, R.P. Shah, S. Singh, Strategy for identification and characterization of small quantities of drug degradation products using LC and LC-MS: Application to valsartan, amodel drug, Drug Test. Anal. 2; 82–90. doi:10.1002/dta.116.
M. Narayanam, T. Handa, P. Sharma, S. Jhajra, P.K. Muthe, P.K. Dappili, R.P. Shah, S. Singh, Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products, J. Pharm. Biomed. Anal. 87; 191–217. doi:10.1016/j.jpba.2013.04.027.
S. Singh, B. Prasad, A.A. Savaliya, R.P. Shah, V.M. Gohil, A. Kaur, Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs, TrAC - Trends Anal. Chem. 28; 13–28. doi:10.1016/j.trac.2008.09.004.

Books/Book Chapters/Patents/Peer Review -Abstracts

Patents

Title: Substentially Pure Canagliflozin.
Country: PCT/World patent.
Filing year: 2017.
Patent application No.: WO 2017/093949

Presentations:
National :	20
International:	03
Projects:
Completed	01
Ongoing	01
PhD:
Completed	00
Ongoing	01
MS Dissertation:
Completed	00
Ongoing	06