Thrust areas: Diabetes and Obesity, Infectious diseases, Cancer, Cardiovascular diseases and Neuronal disorders
Diabetes and Obesity:
- Proteomics and genomics biomarkers for diabetes and its microvascular complications
- Lead based design and development of NCEs of natural pharmacophores as anti-diabetic and anti-obesity leads
- Stabilized lipid vesicular formulation for oral delivery of therapeutic proteins and peptides (Insulin and peptidic incretin hormones such as GLP-1, exendin-4)
- PK-PD herb-drug interaction studies for therapeutic modulation in diabetes
Cancer:
- SNPs and its role in oral cancer in Western Indian population
- Structure-based drug design, synthesis and screening of small molecules, including pro-apoptotic BAX activators
- Thiazole heterocyclic chemical probes and their screening for lung cancer
- Stabilized lipid vesicular formulation for oral delivery of therapeutic proteins and peptides (Buserelin, Abarelix) for prostate cancer and uterine cancer
- Exploring marine algae in search of new leads for treatment of breast cancer and lung cancer
- Cancer stem cell (CSC) re-differentiation, regime for prevention of relapse
- Discovery of new natural products as leads for lung cancer
Cardiovascular diseases:
- Novel and targeted drug delivery systems for angina
- Development of tri-layered tablet formulation for controlled delivery of antihypertensives
- Development of bio-degradable stents and coatings
Neuronal disorders:
- Role of JAK pathway Alzheimer’s disease
- Modulation of microgilal phenotype in neuroinflammation in cerebral ischemia
- Melatonin in traumatic brain injury
- Discovery of new natural products as neuroprotective leads
Other areas:
- Cartilage regeneration by using biodegradable nano-fibre scaffolds
- Osteoconductive coatings for orthopaedic implants
- Bioactive bone grafts for bone regeneration
- Induced pluripotent stem cells
The dedicated faculty at NIPER-A investigates different aspects of human health such as diabetes, tuberculosis, obesity, cancer, neurologic disorders. Research is being conducted across the spectrum
- Proteomics and genomic biomarkers, pharmacogenomics and stem cell research
- Drug discovery and development using molecular modeling
- Drug discovery from natural sources
- Targeted drug delivery system, solid state characterization, QbD in formulation
- Analytical/bioanalytical method development and impurity profiling
- Development of biomaterial for cardiovascular, orthopedic and ocular implants
- Metal toxicology, neurodegeneration, Cognition
We believe in exploring multidisciplinary research in all departments and help the student to excel in their field and develop the skills. NIPER has been actively pursuing the research in different departments
Research Projects
| Project Title |
Principal Investigator |
Sponsoring Agency |
Year |
| Exploring the molecular mechanism of butter oil enriched nanoformulation in enhancing nasal to brain delivery and its potential role in promoting neurogenesis |
PI: Dr.Manju Mishra, Co PI:Dr. Pallab Bhattacharya |
DST SERB |
2017-2020 |
Bioprospecting endolichenicfungi from Mangroves in Negombo lagoon in Sri Lanka and Gulf of Khambat, Gulf of Kutch from Gujarat India; An untapped treasure trove for discovery of special structures and bioactive compounds
(Grant No: DST/INT/SL/P-22/2016) |
Prof. Kiran Kalia Sri Lankan Partner: Prof. Priyali Pranagama University of Kelniya, Sri Lanka |
DST, Indo Sri Lanka Joint Research Program |
2017-2020 |
| Bio-engineered three-dimensional stem cell niche for intervertebral Disc repair and regeneration |
Dr.Akshay Srivastava |
DST SERB |
2017-2020 |
| Regulatory non-coding RNA mediated mesenchymal stem cell engineering: A safety and efficacy study in rodent model of ischemic stroke |
Dr.Pallab Bhattacharya |
DST SERB |
2017-2020 |
| Mitochondrial protection in ischemic stroke by using microRNA mediated engineered stem cells. |
Dr.Pallab Bhattacharya |
ISN,USA |
2017-2020 |
| Dissecting Brain Reward Circuitry & CNS Comorbidities in Chronic Neuropathic Pain . |
Dr.Vinod Tiwari |
DST SERB |
2017-2020 |
| Aptamer targeted dendronized polymeric nanoparticles to deliver Anti-miRNA for treatment of Triple Negative Breast Cancer |
Dr Rakesh Tekade |
DST, SERB India |
2017-2020 |
| Triple punch approach for triple negative breast cancer by delivering siRNA and doxorubicin using graphene oxide wrapped polymeric nanoparticles |
Dr Rakesh Tekade |
DST, SERB India |
2017-2020 |
| A novel strategy to explore endosomal degradation of gene therapeutics |
Dr Rakesh Tekade |
Fundamental Research Grant Scheme, Ministry of Health, Malaysia. |
2016-2018 |
| Synthesis and development of antitubercular 1,4-naphthoquinone congeners asMycobacterium tuberculosis methionine aminopeptidases inhibitors |
Dr. Anita Mahapatra
Dr. Neelam Chauhan (Co-PI) |
DBT |
2013-2016 |
| In-situ gelling mucoadhesive system for brain delivery of p-Glycoprotein (P-gp) substrates via nasal route: Effect of a novel lipidic agent on drug release and P-gp inhibition |
Dr. Manju Misra |
DST, INSPIRE |
2012-2017 |
| Project Title |
Principal Investigator |
Sponsoring Agency |
Year |
| Design of Oral delivery system for macromolecules using gastrointestinal patch system: Role of fatty acid as penetration enhancer |
Dr. Manju Misra |
DBT, RGYI |
2012-2015 |
| A non-viral vector for inducing pluripotency |
Dr. Neelam Chauhan |
DBT, RGYI |
2010-2012 |
| A non-viral vector for inducing pluripotency |
Dr. Neelam Chauhan |
GSBTM |
2010-2012 |
| Biotech pharma link unit for converting biological therapeutics into dosage forms for SMEs |
Dr. Neelam Chauhan (Co-PI) |
IC, Govt. of Gujarat |
2009-2011 |
| Centre of Excellence for Quality Assurance of Drugs |
Dr. Anita Mahapatra |
IC, Govt. of Gujarat |
2009-2011 |
Patents
- Patent Title :Process and Composition for loading, stabilization, and delivery of RNAi Therapeutics in Anionic polymer, Indian Patent Application No. 201921019898(Date: 21/05/ 2019)Name
of Inventor: Nidhi Raval, Hardi Jogi, Piyush Gondaliya, Kiran Kalia, Rakesh Kumar Tekade.
- Patent Title : Targeting Peripheral Neurons using Tramadol hydrochlorideopioid- encapsulated PEGylated albumin nanoparticles for safe and effective antinociceptive activity, Indian Patent No.201921010920 (Date: 20/03/2019).Name
of Inventor : Rakesh K. Tekade, Vinod Tiwari, Pankaj Bidve, Dilip Sharma, Namrata Prajapati, Nidhi Raval, Kiran Kalia.
- Patent Title : Supermacroporus, drug-loaded collagen punctum plug, Indian Patent No.201821045485 (Date: 02/12/2018). Name of Inventor: Akshay Srivastava, Gopal Agarwal, Silvy Mary
Sebastian.
- Patent Title : Mix-and-Deliver-Type’ In Vivo applicable Polymeric Gene Transfecting Reagent for Cancer Therapy, Indian Patent No. 201821043610 (Date: 20/11/2018).Name of Inventor:
Rakesh K. Tekade, Kaushik Kuche, Piyush Gondaliya, VishakhaTambe, Kiran Kalia.
- Patent Title: Graphene Oxide/Polypyrrole/Polyaniline / Zinc Oxide Nanocomposite Based Electrode for Effective Detection of Cholesterol and Bilirubin, Indian Patent Application No. 201821040222 (Date: 25/10/2018).Name
of Inventor: Anup Kumar, Namdev More, Kiran Kalia,and Govinda Kapusetti.
- Patent Title: Minicircle DNA vector for inducing pluripotency in nucleated blood cells and other cell types and its re-differentiation for use in regenerative medicine, Indian Patent No. 201621031592 (Date: 16/09/2016)Name
of Inventor: Neelam Chauhan, Shaishavi Jansari, Kiran Kalia.
- Patent Title: Cartilage Regeneration Using Piezoelectric Based Scaffold” Indian Patent No. 201621008797 (Date: 14/03/2016)Name of Inventor: Govinda Kapusetti, Jaicy Jacob, Kiran
Kalia and Piyush Gondaliya.
- Patent Title : Process of isolation and purification of Swertiamarin from Enicostemme littorale, Indian Patent No. 201621008411 (Date: 10/03/2016)Name of Inventor: Vinod Jairaj,
Satyendra Kumar, Kiran Kalia.
Publications