Honours

• Selected to work on DBT-Piramal funded Mega Project “Screening of Biomolecules from microbial diversity collected from different ecological niches – Part II chemical characterization”
• Awarded research funding from Florida Atlantic University during Ph.D. program
• Recipient of “Gold Medal” in Chemistry and “Silver Medal” in Mathematics during B.Sc. (University topper in chemistry and mathematics)
• Member of Mycological Society of India (Life Member)
• Member of Advisory Panel for Natural Products in Zydus Wellness

Publications

• Monika Sharma, Fehmina Mushtaque Malim, Ashutosh Goswami, Nishant Sharma, Sai Sowmya Juvvalapalli, Sayan Chatterjee, Abhijeet S. Kate, and Amit Khairnar. “Neuroprotective Effect of Swertiamarin in a Rotenone Model of Parkinson’s Disease: Role of Neuroinflammation and Alpha-Synuclein Accumulation.” ACS Pharmacology & Translational Science (2022).
• Pathik Parekh, Nishant Sharma, Monika Sharma, Anagha Gadepalli, Adil Ali Sayyed, Sayan Chatterjee, Abhijeet Kate, and Amit Khairnar. “AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease.” Metabolic Brain Disease 37, no. 8 (2022): 2853-2870.
• Prakash Niguram, and Abhijeet S. Kate. “Comprehensive metabolite identification study of arterolane using hydrophilic interaction liquid chromatography with quadrupole‐time‐of‐flight mass spectrometry.” Rapid Communications in Mass Spectrometry 36, no. 16 (2022): e9335.
• Debanjan Chatterjee, Nazmina Vhora, Ashutosh Goswami, Aishwarya Hiray, Alok Jain, and Abhijeet S. Kate. “In-silico and in-vitro hybrid approach to identify glucagon-like peptide-1 receptor agonist from anti-diabetic natural products.” Natural Product Research (2022): 1-5.
• Chaitrali Shevkar, Ashwini Armarkar, Ramani Weerasinghe, Kasun Maduranga, Komal Pandey, Santosh K. Behera, Kiran Kalia, Priyani Paranagama, and Abhijeet S. Kate. “Cytotoxic Bioxanthracene and Macrocyclic Polyester from Endolichenic Fungus Talaromyces pinophilus: In-Vitro and In-Silico Analysis.” Indian Journal of Microbiology (2022): 1-11.
• Ramani H. Weerasinghe, Chaitrali D. Shevkar, Kasun Maduranga, Komal H. Pandey, Renuka N. Attanayake, Abhijeet S. Kate, Gothamie Weerakoon, Santosh K. Behera, Kiran S. Kalia, and Priyani A. Paranagama. “Bioprospecting of an Endolichenic Fungus Phanerochaete sordida Isolated from Mangrove-Associated Lichen Bactrospora myriadea.” Journal of Chemistry 2022 (2022).
• Chaitrali Shevkar, Pranali Pradhan, Ashwini Armarkar, Komal Pandey, Kiran Kalia, Priyani Paranagama, and Abhijeet S. Kate. “Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds.” Chemistry & Biodiversity 19, no. 4 (2022): e202100976.
• Ruchi Singh, Mini Dhiman, Arvind Saklani, C. Immanuel Selvaraj, and Abhijeet S. Kate. “Isolation and characterization of a novel flavanone glycoside from an endemic plant Haplanthodes neilgherryensis.” Journal of Asian Natural Products Research 24, no. 1 (2022): 96-101.
• Kavya Teja Parusu, Jinal Mithiya, Abhijeet S. Kate, Khemraj Bairwa, and Siddheshwar K. Chauthe. “Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview.” Phytomedicine (2021): 153890.
• Disha Thakkar, Amit Kumar Sahu, Rajeshwari Rathod, Pinaki Sengupta, and Abhijeet S. Kate. “Investigation of the impact of grapefruit juice, pomegranate juice and tomato juice on pharmacokinetics of brexpiprazole in rats using UHPLC–QTOF–MS.” Biomedical Chromatography 35, no. 11 (2021): e5201.
• Ramani H. Weerasinghe, Kasun Maduranga, Renuka N. Attanayake, Chaitrali Shevkar, Abhijeet S. Kate, Gothamie Weerakoon, Kiran Kalia, and Priyani A. Paranagama. “Bioactive properties and metabolite profiles of endolichenic fungi in mangrove ecosystem of Negombo lagoon, Sri Lanka.” Natural Product Communications 16, no. 10 (2021): 1934578X211048652.
• Sanmoy Pathak, Abhijeet Gokhroo, Ashim Kumar Dubey, Shamik Majumdar, Souradeep Gupta, Asha Almeida, Girish B. Mahajan, Abhijeet Kate, Prabhu Mishra, Rajiv Sharma. “7-Hydroxy Frullanolide, a sesquiterpene lactone, increases intracellular calcium amounts, lowers CD4+ T cell and macrophage responses, and ameliorates DSS-induced colitis.” International Immunopharmacology 97 (2021): 107655.
• Akash R. Gohil, Sunil K. Deshmukh, Vaishali Bhattacharya, Rahul Lavhale, Shilpa Verekar, and Abhijeet S. Kate. “Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity.” Natural Product Research 35, no. 10 (2021): 1573-1581.
• Amit Kumar Sahu, Ashutosh Goswami, Abhijeet S. Kate, and Pinaki Sengupta. “Identification and structural characterization of potential degraded impurities of ribociclib by time of flight-tandem mass spectrometry, and their toxicity prediction.” Journal of Pharmaceutical and Biomedical Analysis 197 (2021): 113933.
• Preeti Bharatiya, Pooja Rathod, Aishwarya Hiray, and Abhijeet S. Kate. “Multifarious elicitors: Invoking biosynthesis of various bioactive secondary metabolite in fungi.” Applied Biochemistry and Biotechnology 193, no. 3 (2021): 668-686.
• Maduranga, H., W. Weerasinghe, R. Attanayake, S. Santhirasegaram, C. Shevkar, A. Kate, G. Weerakoon, K. Samanthi, K. Kalia, and P. A. Paranagama. “Identification of novel bioactive compounds, neurosporalol 1 and 2 from an endolichenic fungus, Neurospora ugadawe inhabited in the Lichen host, Graphis tsunodae Zahlbr. from mangrove ecosystem in Puttalam Lagoon, Sri Lanka.” (2021).
• Prakash Niguram, Ashutosh Goswami, and Abhijeet S. Kate. “A novel hydrophilic interaction liquid chromatography method for the analysis of arterolane; Isolation and structural elucidation of its major degradation product by LC-HRMS and NMR.” Journal of Pharmaceutical and Biomedical Analysis 186 (2020): 113279.
• Naidu, K. Sattaiah, Abhijeet S. Kate, Vikas Kshirsagar, R. Ganeshan, Tukaram Gunale, Bing Zhou, Samir Anapat, Yusuf Sulub, Arun Kumar, and Narayana Rao. “A spectrophotometric method for estimation of titanium alkoxide, a catalytically active form of titanium in oligomer/polymers.” Polymer Testing 86 (2020): 106446.
• Disha Thakkar and Abhijeet S. Kate. “1-(Benzo [b] thiophen-4-yl) piperazine Ring Induced Bioactivation of Brexpiprazole in Liver Microsomes: Identification and Characterization of Reactive Conjugates Using Ultra-High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry.” European Journal of Drug Metabolism and Pharmacokinetics 45 (2020): 393-403.
• Shital P. Patil, Ashutosh Goswami, Kiran Kalia, and Abhijeet S. Kate. “Plant-derived bioactive peptides: A treatment to cure diabetes.” International Journal of Peptide Research and Therapeutics 26 (2020): 955-968.
• Disha Thakkar and Abhijeet S. Kate. “Update on metabolism of abemaciclib: In silico, in vitro, and in vivo metabolite identification and characterization using high resolution mass spectrometry.” Drug Testing and Analysis 12, no. 3 (2020): 331-342.
• Komal Pandey, Chaitrali Shevkar, Khemraj Bairwa, and Abhijeet S. Kate. “Pharmaceutical perspective on bioactives from Alstonia scholaris: ethnomedicinal knowledge, phytochemistry, clinical status, patent space, and future directions.” Phytochemistry reviews 19 (2020): 191-233.
• Prakash Niguram, Surya Narayana Polaka, Rajeshwari Rathod, Kiran Kalia, and Abhijeet S. Kate. “Update on compatibility assessment of empagliflozin with the selected pharmaceutical excipients employed in solid dosage forms by thermal, spectroscopic and chromatographic techniques.” Drug Development and Industrial Pharmacy 46, no. 2 (2020): 209-218.
• Abhijeet Parkhe, Pathik Parekh, Lakshmi Vineela Nalla, Nishant Sharma, Monika Sharma, Anagha Gadepalli, Abhijeet Kate, and Amit Khairnar. “Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson’s disease.” Neuroscience letters 716 (2020): 134652.
• Prakash Niguram and Abhijeet S. Kate. “Structural characterization of forced degradation products of empagliflozin by high resolution mass spectrometry.” Journal of Liquid Chromatography & Related Technologies 42, no. 13-14 (2019): 417-428.
• Disha Thakkar and Abhijeet S. Kate. “In silico, in vitro and in vivo metabolite identification of brexpiprazole using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry.” Rapid Communications in Mass Spectrometry 33, no. 11 (2019): 1024-1035.
• Abhijeet S. Kate, and K. C. Basavaraju. “A simple potentiometric titration method for estimation of maleic anhydride in high molecular weight styrene-maleic anhydride copolymer.” Polymer Testing 65 (2018): 369-373.

Research Scholars

Student Details

Ashutosh Goswami

PhD Scholar
Project title:
Identification and characterization of peptides/small molecules as glucagon like peptide-1 receptor agonist from plants possessing antidiabetic potential

Chaitrali Shevkar

PhD Scholar
Project Title: Isolation and Characterisation of novel Anticancer molecules from Endolichenic/Endophytic Fungi

Shamana Gondaliya

PhD Scholar

Dr. Komal Pandey

PhD (2016-2023)

Dr. Prakash Niguram

PhD (2015-2021)

Dr. Disha Thakkar

PhD (2015-2022)

Gopal Ede

MS student
Project Title: Isolation and characterization of novel secondary metabolites from marine ecosystem.

Ankita Ghane

MS Student
Project title: Identification of chemical markers of Enicostemma littorale and assessment of stability study.

Kaveri Pawar

MS Student
Project Title: Isolation of Cytotoxic molecules from Endolichenic fungus Aspergillus Flavus

Expertise

Abhijeet graduated from Florida Atlantic University in Boca Raton, FL, USA, with a Ph.D. in Marine Natural Products in 2008. He has worked for prominent companies like Piramal Enterprises Limited and SABIC during his 13 years in the industry. Since 2017, he has been associated with the National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, where he is currently working as an Associate Professor and Head, The Department of Natural Products. He holds 3 patents and published more than 35 papers in the field of natural products and analytical research.
In Natural Products-based drug discovery programs, he has optimized LC-HRMS dereplication methods, downstream processes for large-scale isolation of Natural Products, and created a methodology for fingerprinting of extracts by LC-UV-MS. He is most interested in discovering novel scaffolds from marine and terrestrial bacteria, fungi, and plants. A team led by Dr. Abhijeet is looking into lichens of Gujarat for the presence of bioactive molecules. In an effort to discover the treatment for diabetes, his team is finding a natural product that can bind GLP-1 receptor and enhance insulin secretion.

Group Photos

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