Dr. Bichismita Sahu, Ph.D.
Associate Professor , Department of Medicinal Chemistry
-
bichismita[at]niperahm[dot]ac[dot]in, bichismita[at]niperahm[dot]res[dot]in -
+91 79 66745555, +91 8424022096 -
NIPER-Ahmedabad -
Gandhinagar
Dr. Bichismita Sahu has completed her master degree in Organic Chemistry from Ravenshaw University, Cuttack, Orissa and PhD from Indian Institute Technology, Bombay (IIT-Bombay) under supervision of Prof. I.N. N Namboothiri. She has extensive experience in PEPTIDE NUCLEIC ACID synthesis from Carnegie Mellon University, Pittsburgh , USA under mentorship of Prof. Danith H. Ly who is the pioneer in Peptide- Nucleic Acid. She is one of the co-inventor PEGylated gammaPNA. She has several years of industrial experience in NCE-Drug Discovery and API. At NIPER-Ahmedabad, her group is actively working towards Peptides, Peptidomimetics, NCEs, Enzyme stable short peptides, polymer-peptide conjugates, functional biopolymers for drug discovery (Cancer, CNS disorder), Novel targeted drug delivery systems and Molecular self-assembly based peptide hydrogel. One of her research interest to mimic Antibody by short peptide fragments. She has published many research articles and inventors/co-inventors of several patents.
Research Interest
- Short and ultrashort-peptides, peptoids and nucleic acids for therapeutic and diagnostic applications in Cancer, Epigenetics and CNS disorder.
- Peptide-polymeric scaffolds for biomedical applications (Wound healing, Tissue culture and on Demand drug delivery system)
- Ultrashort peptide based molecular self-assembly, hydrogels
- Deconvolution of antibody for circulating tumor managements
- Development of industrial viable process for API.
- Nucleobase and Aminoacid modification
Experience
- Dec 2019-Present
Associate Professor
NIPER- Ahmedabad, Palaj, Gandhinagar
- Jan 2019-Dec 2019
Assistant Professor
NIPER- Ahmedabad, Palaj, Gandhinagar
- Oct 2018–Jan 2019
Consultant (Drug Discovery)
KrishBioTech-Kolkata
- Mar 2016- Aug 2018
Manager (R&D-API )
ASolution Pharma, Ambernath, Mumbai
- Jan 2015- Feb 2016
Scientist
Laboratory for advanced research; KET, Mumbai
- Aug 2012-Oct 2014
Senior research scientist
Piramal Enterprises, Mumbai
- Oct 2009-Aug 2011
Research scientist
Piramal Life Science Limited, Mumbai
- Sept 2006-Aug 2009
Post Doctoral Fellow
Carnegie Mellon University, Pittsburgh, USA
Honours
Honours/Awards
- Prof. Indira Parikh 50 Women in Education Leaders-2022
- Team award- Piramal Life Science Ltd (PLSL), Mumbai-2011
- Senior Research Fellowship (SRF) sponsored by Council of Scientific and Industrial Research (CSIR), India-2003
- Junior Research Fellowship (JRF) sponsored by Council of Scientific and Industrial Research (CSIR), India-2001
- Qualified All India level Graduate Aptitude Test in Engineering (GATE)-2001
Publications
- Dalvi Tanay, Dewangan Bhaskar, Agarwal Gopal, Shinde Suchita Dattatray, Jain Alok, Srivastava Akshay,Bichismita Sahu. (2021). Design, Synthesis And In-vitro Evaluation Of Fluorinated Triazoles as Multi-Target Directed
Ligands for Alzheimer Disease, Bioorganic & Medicinal Chemistry Letters. 127999. doi.org/10.1016/j.bmcl.2021.127999 - Neeraj Kulkarni, Suchita Dattatray Shinde, Govinda Shivaji Jadhav, Diksha Ramesh AdsareDiksha Ramesh Adsare, Kamya Rao, Mihir Kachhia, Mohit Maingle, Shubham Prakash Patil, Neha Arya, andBichismita Sahu. (2021). Peptide-Chitosan
Engineered Scaffolds for Biomedical Applications, Bioconjugate Chemistry. doi.org/10.1021/acs.bioconjchem.1c00014 - Iulia Sacui , Wei-Che Hsieh , Arunava Manna ,Bichismita Sahu , and Danith H. Ly “Gamma peptide nucleic acids: As orthogonal nucleic acid recognition codes for Organizing molecular self-assembly” J. Am. Chem. Soc., 2015,
137 (26), 8603–8610 - Venkatasubbaiah A Venkatesha, Asavari A Joshi, Magesh Venkataraman, Vinay Sonawane, Prashant K Pandey, Julie Bose, Sarika A Choudhari, Dimple Bhatia, Ankita Srivastava, Vaibhavi Lad, Parkash Gill, Ramachandra Sangana, Tausif Ahmed, Anagha Damre, Vijaykumar
Deore, Bichismita Sahu, Sanjay Kumar, Somesh Sharma and Veena Agarwal “P7170, a novel inhibitor of mTORC1/mTORC2 and Activin Receptor- Like Kinase 1 (ALK1) inhibits the growth of Non Small Cell Lung Cancer” Molecular Cancer
2014, 13, 259 - Sufi M. Thomas; Bichismita Sahu; Srinivas Rapireddy; Raman Bahal; Sarah E. Wheeler; Eva M. Procopio; Joseph Kim; Sonali C. Joyce; Sarah Contrucci; Yun Wang; Kira L. Lathrop; Simon Watkins; Jennifer R. Grandis; Bruce
A. Armitage; Danith H. Ly “Antitumor Effects of EGFR Antisense Guanidine-basedPeptide Nucleic Acids in Cancer Models” ACS Chemical Biology (2013), 8(2), 345-352 - Bichismita Sahu, Guddeangadi N. Gururaja, Anamitra Chatterjee, Bishwajit Ganguly, Shaikh M. Mobin, and Irishi N. N. Namboothiri “Generation and Trapping of a Cage Annulated Vinylidenecarbene and Approaches to Its Cycloalkyne
Isomer” J. Org. Chem. 2012, 77(16), 6998-7004 - BichismitaSahu , Iulia Sacui , Srinivas Rapireddy , Kimberly J. Zanotti , Raman Bahal , Bruce A Armitage , and Danith H. Ly “Synthesis and Characterization of Conformationally- Preorganized, MiniPEG-Containing gammaPNAs
with Superior Hybridization Properties and Water Solubility” J. Org. Chem., 2011, 76 (14), 5614– 5627 - Nilambari Yewalkar, Vijaykumar Deore, Amol Padgaonkar, Sonal monohar,
Bichismita Sahu, Pramod kumar, Archana jalota-Badhwar, Kalpana S. Joshi, someshsharma and sanjaykumar “Development of novel inhibitors targeting HIF-1alpha towards anticancer drug discovery ” Bioorganic and medicinal Chemistry letters, 2010, 20, 6426-6429. - Gaofei He, Srinivas Rapireddy, Raman Bahal,Bichismita Sahu and Danith H. Ly “Strand- Invasion of Extended, Mixed-Sequence B-DNA by ?PNAs” J. Am. Chem. Soc 2009, 131 (34), 12088–12090.
- Bichismita Sahu, Guddeangadi N. Gururaja, Shaikh M. Mobin, and Irishi N. N. Namboothiri “Facile Synthesis of ß-Tribromomethyl and DibromomethylenatedNitroalkanes via Conjugate Addition of Bromoform to Nitroalkenes”
J. Org. Chem., 2009, 74 (6), 2601- 2604 - Bichismita Sahu, Venugopal Chenna, Kira L. Lathrop, Sufi M. Thomas, Gerald Zon, Kenneth J. Livak, and Danith H. Ly “Synthesis of Conformationally Preorganized and Cell- Permeable Guanidine-Based ?-Peptide Nucleic Acids
(?GPNAs)” J. Org. Chem., 2009, 74 (4), 1509-1516 - Bichismita Sahu, R. Muruganantham, I. N. N. Namboothiri; “Synthetic and Mechanistic Investigations on the Rearrangement of 2,3-Unsaturated 1,4-Bis(alkylidene)carbenes to Enediynes” Eur. J. Org. Chem. 2007, 15, 2477-2489
Laboratory for Peptide and Nucleic acid Synthesis
Peptides and nucleic acid based molecules as therapeutics
Solid phase peptide synthesis
Peptide isolation and characterization
Nucleobase modification and infused materials
Peptide based hydrogel
Research Scholar
Student Details
Suchita Shinde
PhD Scholar
Project: Backbone Modified Peptide based Molecular Self-assembly
Neeraj Kulkarni
PhD Scholar
Project:Nucleobase and peptide infused biomaterials for the injury related to the CNS
Bhaskar Dewangan
PhD
Project: Multimodal molecules as Amyloid beta inhibitor
Govinda Yadav
PhD
Project: Fluorinated molecules and materials for oral cancer and wound related to it.
Stephin Baby
PhD
Project: Development of reversible LSD1 inhibitors
Achievements
Novel peptido-hyaluronates; Synthesis and evaluation as a hydrogel for the treatment of head and neck cancer induced oral mucositis (DST-SERB, 21.32 Lakh); PI-Dr. Bichismita Sahu
Served as expert members for syllabus revision GNLU
External examiner for SRC of PhD scholar (Nirma University)