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Dr. Dinesh Kumar, Ph.D.

Assistant Professor , Department of Medicinal Chemistry

Dr Dinesh Kumar received his B. Pharm. from Manipal University (In), M.S. (Pharm.), and a Ph.D. in medicinal chemistry under the guidance of Prof. Asit K. Chakraborti from NIPER SAS Nagar, Punjab India. Subsequently, he moved to Dakota State University (NDSU), USA, and worked as a postdoctoral fellow with Prof. Gregory R. Cook. Currently, he is working as an assistant professor and Ramanujan Fellow at NIPER Ahmedabad, India. His current research focuses on the development of new strategies and concepts in sustainable organic chemistry to address challenging problems in biomedical research and APIs synthesis.

Laboratory of Green Medicinal Chemistry

Research Interest

  • Development of new strategies and concepts in synthetic organic chemistry to address challenging problems in biomedical research, particularly anti-cancer drug discovery.
  • Development of new reaction methodologies
  • Discovery of anti-cancer drug candidates
  • Multi-step synthesis of pharmaceuticals and bioactive natural products
  • Green chemistry

Experience

  • Sept. 2017 - Present
    Assistant Professor

  • Sept. 2018 - Present
    Ramanujan Fellow

    NIPER-Ahmedabad (INDIA)

  • Nov. 2013 – Sept. 2017
    Post-doctoral Fellow

    Department of Chemistry & Biochemistry,North Dakota State University (NDSU), Fargo, USA

  • April 2011 - Nov. 2013
    CSIR-Research Associate (CSIR-RA)

    Department of Medicinal Chemistry, NIPER SAS Nagar (Mohali), India

  • April 2009 - March 2013
    CSIR-Senior Research Fellow (CSIR-SRF)

    Department of Medicinal Chemistry, NIPER SAS Nagar (Mohali), India

Honours

Awards

  • Best Poster award at 2nd KU-NDSU Joint Symposium on Biotechnology, Nanomaterials and Polymers, Fukushima, Japan, November 2016.
  • 1st Prize of 2013 Eli Lilly and Company Asia Outstanding Thesis Awards.
  • Research Associateship (2011) by Human Resource Development Group, Council of Scientific & Industrial Research (CSIR-HRDG), Government of India.
  • Best Poster award at 14th International Conference (ISCBC-2010) on Chemical Biology for Discovery: Perspectives and Challenges, January 2010, CDRI, Lucknow, India.
  • Senior Research Fellowship (2009) by Human Resource Development Group, Council of Scientific & Industrial Research (CSIR-HRDG), Government of India.
  • Graduate Aptitude Test in Engineering (GATE–2005 category: Pharmaceutical Sciences) with 98.64 percentile

Publications

  • Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek Singh, Rachana Garg*, Amit Mandoli*, Dinesh Kumar, * Discovery of fluorinated 2-styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer, Submitted, Bioorganic Chem. 2022 (Manuscript ID: BIOORG-D-22-02586).
  • Gargi Nikhil Vaidya, Ashwini Venkatesh, Deep Rohan Chatterjee, Pooja Rana, Mithilesh Nagpure, Dinesh Parshuram Satpute, Shyam Lokhande, Kiran Kalia,* Dinesh Kumar,* The Rise and Fall of Hydroxychloroquine (HCQ) in COVID Era: A Therapeutic Journey and Synthetic Progress
    ChemRxiv. https://chemrxiv.org/engage/chemrxiv/article-details/62cee93f7aab585379bbe40b
  • Dinesh Kumar, Himanshu Sharma, Nirjhar Saha, and Asit K. Chakraborti,* Domino synthesis of functionalized pyridine carboxylates under gallium catalysis: Unravelling the reaction pathway and the role of the nitrogen source counter anion, Chem Asian J. 2022, 17, e202200304.
  • Sangita Dattatray Shinde, Dinesh Parshuram Satpute, Santosh Kumar Behera, Dinesh Kumar,* Computational Biology of BRCA2 in Male Breast Cancer, Through Prediction of Probable nsSNPs, and Hit Identification, ACS Omega, 2022, 7, 30447–3046.
  • Gargi Nikhil Vaidya, Shyam Kumar Lokhande, Sangita Dattatray Shinde, Dinesh Parshuram Satpute, Garvita Narang, Dinesh Kumar,* Water Enabled, Nickel-Catalyzed Highly Chemoselective C-Allylation of (NH)-Indoles Employing Alcohols, Green Chem., 2022, 24, 4921-4927.
  • Gargi N. Vaidya, Ramesh Hiralal Choudhary, Mithilesh Nagpure, Shyam Kumar Lokhande, Pooja Rana, Dinesh Kumar,* ‘In-Water’ Nickel-Catalyzed Allylic Aminations using Alcohols: Application to “All-Water” Synthesis of Pharmaceuticals”, Flunarizine, Cinnarizine, and Naftifine, Green Chem., 2022, 24, 3977-3984. (2022 HOT Article).
  • Dinesh Parshuram Satpute, Gargi N. Vaidya, Shyam Kumar Lokhande, Sangita Dattatray Shinde, Shivkanya Bhujbal, Deep Rohan Chatterjee, Pooja Rana, V. Ashwini, Mithilesh Nagpure, Dinesh Kumar,* Organic reactions in aqueous media catalyzed by nickel, Green Chem., 2021, 23, 6273-6300.
  • Gargi Nikhil Vaidya, Mithilesh Nagpure, Dinesh Kumar,* Borrowing Carbonate-Enabled Allylic Amination Reactions under Additive- and Reductant-Free Nickel Catalysis Employing Allylic Alcohols, ACS Sustain. Chem. Eng., 2021, 9, 1846.
  • Manish Kumar Sharma, Komal Pandey, Ravi P. Shah, Dinesh Kumar, Pinaki Sengupta,* A mechanistic explanation on the degradation behavior of flibanserin for identification and characterization of its potential degradants using LC-DAD/ESI/APCIQ-TOF-MS/MS, Microchemical Journal, 2021, 167, 106281.
  • Santosh Kumar Behera, Nazmina Vhora, Darshan Contractor, Amit Shard,* Dinesh Kumar,* Kiran Kalia,* Alok Jain,* Simultaneous Inhibition of Entry and Replication of Novel Corona Virus by Grazoprevir: A Computational Drug Repurposing Study, Sci. Rep. 2021, 11, 7307.
  • Gargi Nikhil Vaidya, Pooja Rana, Ashwini V., Deep Rohan Chatterjee, Darshan Contractor, Dinesh Parshuram Satpute, Mithilesh Nagpure, Alok Jain, Dinesh Kumar,* Paradigm shift of “classical” HDAC inhibitors to “hybrid” HDAC inhibitors in therapeutic interventions, Eur. J. Med. Chem. 2021, 209, 112844.
  • Shyam Kumar Lokhande, Gargi Nikhil Vaidya, Dinesh Parshuram Satpute, Ashwini V, Sanjeev Kumar, Dinesh Kumar,* Structure Ligation Relationship of Amino Acids for the Selective Indole C-H Arylation Reaction: L-Aspartic acid as Sustainable Alternative of Phosphines Ligands Adv. Syn. Catal. 2020, 362, 2857.
  • Sanjeev Kumar, Dinesh Parshuram Satpute, Gargi Nikhil Vaidya, Mithilesh Nagpure, Shyam Kumar Lokhande, Deepak Kumar Meena, Dinesh Kumar,* Micellar catalysis enabled synthesis of indolylbenzothiazoles and their functionalization via Mn(II)-catalyzed C2–H amination using pyridones Tetrahedron Lett. 2020, 61, 152017.
  • Gargi Nikhil Vaidya, Sneha Fiske, Hansa Verma, Shyam Kumar Lokhande, Dinesh Kumar,* A micellar catalysis strategy applied to the Pd-catalyzed C–H arylation of indoles in water, Green Chem., 2019, 21, 1448. (Highlighted in Organic Process Research & Development under section Industry Relevant Research).
  • 15) Gargi Nikhil Vaidya, Arif Khan, Hansa Verma, Sanjeev Kumar, Dinesh Kumar,* Structure ligation relationship of amino acids for the amination cross-coupling reactions, J. Org. Chem., 2019, 84, 3004.
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