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Dr. Hemant Kumar, Ph.D.

Assistant Professor , Department of Pharmacology and Toxicology

Research Interest

  • The death of the endothelial cell continues throughout the acute phase of the spinal cord injury (SCI), predominantly at the injury epicenter.
  • My major research area is to find the target or NCEs for endothelial protection/stabilization within penumbral microvasculature and preserving the blood-spinal cord barrier integrity.
  • Additionally, I am also evaluated the effect of biomaterials/nanoparticles on the injured spinal cord.
  • Additionally, I have vast experience in animal model development in diverse therapeutic areas, including spinal cord injury, IVDD, Parkinson’s disease, neuropathic & inflammatory pain, multiple sclerosis, and arthritis.

Experience

  • January 2020 -Present
    Assistant Professor

    NIPER- Ahmedabad, Palaj, Gandhinagar

  • September 2017 – January 2020
    Assistant Professor

    CHA University South Korea

  • December 2015 – August 2017
    Korean Research Fellow

    CHA University, South Korea

  • December 2009 – February 2011
    Senior Research Biologist

    Chembiotek (TCG Lifescience),Kolkata

  • April 2009 – December 2009
    Research officer

    Glenmark Pharmaceuticals,Mumbai

  • May 2007 – March 2009
    Research Associate

    Glenmark Pharmaceuticals, Mumbai

  • June 2006 – March 2007
    Research Trainee

    CDRI,Lucknow

Honours

  • Brain Korea-21 (BK-21) scholarship for doing Ph.D
  • BK-21 award for the year 2012-2013 and 2013-2014 (Highest impact factor).
  • Full scholarship assistance for doing Master’s by Government of India (GATE).
  • Korea Research Fellowship (KRF) for doing Postdoc.
  • Best Oral presentation award in Biospine Asia Pacific 2018 held at Yonsei University April 27, 2018.
  • Wiltse Academic Award at the 32nd Annual meeting of the Korean Spinal Neurosurgery Society September 14, 2018.

Publications

    Selected Publication

  • Songhyun Lim, Seong Bae An, Mungyo Jung, Hari Prasad Joshi,
    Hemant Kumar
    , Cheesue Kim, Seuk Young Song, Ju-Ro Lee, Mikyung Kang, Inbo Han, Byung-Soo Kim. (2021). Local Delivery of Senolytic Drug Inhibits Intervertebral Disc Degeneration and Restores Intervertebral Disc Structure, Advanced Healthcare Materials.
    2101483. https://doi.org/10.1002/adhm.202101483
  • Kirti Adhikari, Sonam Dolma, Teena Mamidi, Abhishek Roy, Zarna Pathak, and
    Hemant Kumar
    . (2021). Tomographic Imaging and Correlation to Quantify Vascular and Inflammatory Changes in an Experimental Spinal Cord Injury, ACS Chemical Neuroscience. org/10.1021/acschemneuro.1c00390
  • Mounika Choppadandi, Aditya Teja Guduru , Piyush Gondaliya , Neha Arya, Kiran Kalia,Hemant Kumar, Govinda Kapusetti. (2021). Structural Features Regulated Photoluminescence Intensity and Cell Internalization of Carbon
    and Graphene Quantum Dots for Bioimaging, Materials Science and Engineering: C. 112366. doi.org/10.1016/j.msec.2021.112366
  • Abhishek Roy, Zarna Pathak, Hemant Kumar. (2021). Strategies to neutralize RhoA/ROCK pathway after spinal cord injury, Experimental Neurology. 343, doi.org/10.1016/j.expneurol.2021.113794
  • Sonam Dolma & Hemant Kumar. (2021). Neutrophil, Extracellular Matrix Components, and Their Interlinked Action in Promoting Secondary Pathogenesis After Spinal Cord Injury, Molecular Neurobiology. doi.org/10.1007/s12035-021-02443-5
  • Kumar H, Lim CS, Choi H, Joshi HP, Kim K-T, Kim YH, et al. Elevated TRPV4 levels contribute to endothelial damage and scarring in experimental spinal cord injury. Journal of Neuroscience. 2020. 40 (9) 1943-1955, (I.F-
    6.07)
  • Kumar H, Choi H, Jo M-J, Joshi HP, Muttigi M, Bonanomi D, et al. Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury. Acta neuropathologica communications.
    2018;6(1):1-18. (I.F- 5.88)
  • Kumar H, Lee S-H, Kim K-T, Zeng X, Han I. TRPV4: a sensor for homeostasis and pathological events in the CNS. Molecular neurobiology. 2018;55(11):8695-708. (I.F- 4.58)
  • Kim HY$,Kumar H, Jo M-J, Kim J, Yoon J-K, Lee J-R, et al. Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment. Nano letters.
    2018;18(8):4965-75. (Co-first) (I.F- 12.27)
  • Kumar H, Ha D-H, Lee E-J, Park JH, Shim JH, Ahn T-K, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic
    discogenic low back pain: 1-year follow-up of a phase I study. Stem cell research & therapy. 2017;8(1):262. (I.F- 4.62)
  • Kim HJ, Lim CS, Lee HW, Lee HS, Um YJ, Kumar H, et al. A ratiometric two-photon probe for Ca2+ in live tissues and its application to spinal cord injury model. Biomaterials. 2017;141:251-9. (I.F-10.27)
  • Kumar H, Jo M-J, Choi H, Muttigi MS, Shon S, Kim B-J, et al. Matrix Metalloproteinase-8 Inhibition Prevents Disruption of Blood–Spinal Cord Barrier and Attenuates Inflammation in Rat Model of Spinal Cord Injury. Molecular
    neurobiology. 2018;55(3):2577-90. (I.F- 4.58)
  • Ahn J$,Kumar H,Cha BH, Park S, Arai Y, Han I, et al. AIMP1 downregulation restores chondrogenic characteristics of dedifferentiated/degenerated chondrocytes by enhancing TGF-β signal. Cell death & disease. 2017;7(2):e2099.
    (Co-first) (I.F- 5.95)
  • Kumar H, Kim I-S, More SV, Kim B-W, Choi D-K. Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Natural product reports. 2014;31(1):109-39. (I.F- 11.87)
  • Kumar H,Choi D-K. Hypoxia inducible factor pathway and physiological adaptation: a cell survival pathway? Mediators of inflammation. 2015;2015. (I.F- 3.54)

SCiDD Lab

Endothelial and ECM remodeling in Spinal Cord Injury and Intervertebral Disc Degeneration
For more details, Visit Link

Research Scholars

Student Details

Abhishek Roy

Abhishek did his bachelor of pharmacy from Calcutta institute of pharmaceutical technology and allied health sciences in 2017 and M.S (Pharm.) Pharmacology and Toxicology from NIPER Mohali in 2019.
Currently he is working on “Exploring microtubule stabilization and actin microfilaments dynamics in spinal cord injury” for his PhD thesis
Contact: abhishek.roy@niperahm.res.in

Zarna Pathak

Zarna did her bachelor of pharmacy from Dharamsinh Desai University in 2016 and her M.Pharm in Pharmacology from KSV University in 2018.
Currently, she is working on “Exploring the role of IFN-γ & its receptors in autoimmune and traumatic demyelination” for her Ph.D. thesis
Contact: zarna.pathak@niperahm.res.in

Manjeet Chopra

Manjeet Chopra Manjeet did his bachelor of pharmacy from Kurukshetra University in 2018 and M.S (Pharm.) Pharmacology and Toxicology from NIPER Mohali in 2020.
Currently, he is working on “Transcriptomic and proteomic profiling followed by spinal cord Injury” for his PhD thesis
Contact: manjeet.chopra@niperahm.res.in

Nidhi Singh

Nidhi did her bachelor of pharmacy from Kanpur University in 2016 and M.S (Pharm.) Biotechnology from NIPER Hajipur in 2018.
Currently, she is working on “Evaluation of Cellular and Molecular Mechanisms of Rab27 protein in SCI: a plausible role in axonal degeneration” for her PhD thesis.
Contact: nidhi.singh@niperahm.res.in

Divya Goyal

Divya did her bachelor of pharmacy from B.S. Anangpuria College of Pharmacy Faridabad in 2019 and M.S (Pharm.) Pharmacology and Toxicology from NIPER Raebareli in 2021.
Currently, she is working on “Inhibition of myofibroblast trans-differentiation induced fibrotic scarring via targeting RAS and TGF-beta1 in spinal cord injury” for her Ph.D. thesis
Contact: divya.goyal@niperahm.res.in

Lahanya Guha

Lahanya did his bachelor of pharmacy from NSHM knowledge campus in 2019 and M.S (Pharm.) Pharmacology and Toxicology from NIPER Mohali in 2021.
Currently, he is working on “To explore the role of neurotrophins on trauma-induced male sexual dysfunction in the experimental model(s) of spinal cord injury” for his Ph.D. thesis.
Contact: lahanya.guha@niperahm.res.in

Gyanoday Tripathi

Gyanoday did his bachelor of pharmacy from AKS University in 2019 and M.S (Pharm.) Pharmacology and Toxicology from NIPER Kolkata in 2021.
Currently, he is working on “Exploring the role of transmembrane proteoglycan in Intervertebral Disc Disease and Spinal Cord Injury” for his PhD thesis.
Contact: gyanoday.tripathi@niperahm.res.in

Aditya A. Singh

Aditya did his Bachelor of Pharmacy from University of Mumbai in 2019 and M.S (Pharm.) Pharmacology and Toxicology from NIPER Hyderabad in 2021.
Currently, he is working on “Delineating metabolic and molecular landscapes associated with TRPV1 channel in animal model(s) of Parkinson’s disease” for his Ph.D. thesis.
Contact: aditya.singh@niperahm.res.in

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