![IMG-9999](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-9999-scaled.jpg)
![Ravi Shah](https://niperahm.ac.in/wp-content/uploads/2022/11/dr-ravi-shah.jpg)
Dr. Ravi Shah, Ph.D.
Associate Professor , Department of Pharmaceutical Analysis
Research Interest
Development of analytical strategies for drug development and discovery with specific focus on:
- Characterization of complex APIs and biosimilars
- Characterization of complex formulations and sameness strategy development for regulatory submission
- In-vitro release and its correlation with formulation strategies
- Bioanalytical, biomarker analysis and metabolomics
- LC-MS and NMR based characterization of impurities, drug-drug/ drug-excipient interaction products and degradation products
- Pre-formulation assessment including polymorph characterization, salt screening, drug- excipient compatibility studies, rheological assessment, particle properties
Experience
- 2019 – Present
Associate Professor
Department of Pharmaceutical Analysis, NIPER Ahmedabad, Gujarat, India
- August 2015 – February 2019
Principal Scientist, Associate Director
AR&D,Integrated Product Development Organization, Dr. Reddy’s Laboratory, Bangalore
- April 2015 - July 2015
Senior Principal Investigator
AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
- May 2013 – March 2015
Principal Investigator
AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
- April 2011 – April 2013
Research Investigator
AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
- Octomber 2010 – March 2011
Associate Scientific Manager
AR&D Biocon-Bristol Myers Squibb R&D Center, Bangalore
- July 2007 – September 2010
PhD Scholar
Department of Pharmaceutical Analysis, NIPER-SAS Nagar, Mohali
Honours
Awards
- PoC of the Year 2018, Dr. Reddy’s Laboratories.
- Galaxy BMS Award, Biocon-Bristol Myers Squibb R&D Center.
- Team Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
- Individual Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
- Golden R&D Star Award, Biocon-Bristol Myers Squibb R&D Center.
- Team Triumph Award, Biocon-Bristol Myers Squibb R&D Center.
- Golden R&D Star Award, Biocon-Bristol Myers Squibb R&D Center.
- AAPS Travel Award, American Association of Pharmaceutical Scientists.
- Best Poster Presentation Award, Indian Pharmaceutical Congress.
- Innocentive award with Cash prize of US $15000, Innocentive Inc.
- Second prize in oral presentation, Indian Society for Mass Spectrometry.
- DST Travel Award for presenting research work at British Pharmaceutical Conference.
- Best Out-Going Student of the batch: B.Pharm 2001-2005 SGRS CoP, Pune University.
- Merit Scholarship Award, Sir Ratan Tata Trust.
Publications
- Kalyani Sharma, Harsh Thakkar, Nancy Goyal and
Ravi P. Shah,. (2021). LC-HRMS Studies on Ruxolitinib Degradation: A Comprehensive Approach during Drug Development, Analytical Methods. doi.org/10.1039/D1AY01915E - Manish Kumar Sharma, Amit Kumar Sahu, Ravi P. Shah,, Pinaki Sengupta. (2021). A systematic UHPLC-Q-TOF-MS/MS based analytical approach for characterization of flibanserin metabolites and establishment of biotransformation
pathway, Journal of Chromatography B. 123011, doi.org/10.1016/j.jchromb.2021.123011 - Harsh Thakkar, Rameswari Eerla, Shriya Gangakhedkar,
Ravi P. Shah. (2021). Exploring Unexplored Biomarkers of Oxidative Distress and their Use, Advances in Redox Research. 100020, https://doi.org/10.1016/j.arres.2021.100020 - Sagar Salave, Sonali Jain, Ambika Chamoli, Amit Mandoli,
R.P. Shah, Kiran Kalia, Derajram Benival. (2020). Role Of Biologicals For Combating Covid-19: A Systematic Review, World Journal Of Pharmacy And Pharmaceutical Sciences,9(12), 456-484. DOI: 10.20959/wjpps202012-17770 - Manish Kumar Sharma, R.P. Shah,, Pinaki Sengupta. (2020). Amalgamation of Stress Degradation and Metabolite Profiling in Rat Urine and Feces for Characterization of Oxidative Metabolites of Flibanserin using UHPLC-Q-TOF-MS/MS,
H/D Exchange and NMR Technique, Journal of Chromatography B. 121993. doi.org/10.1016/j.jchromb.2020.121993 - R.P. Shah, A. Garg, S.P. Putlur, S. Wagh, V. Kumar, V. Rao, S. Singh, S. Mandlekar, S. Desikan, Practical and economical implementation of online H/D exchange in LC-MS., Anal. Chem. 85; 10904–10912. doi:10.1021/ac402339s.
- R.P. Shah, V. Kumar, S. Singh, Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products., Rapid Commun. Mass Spectrom. 22; 613–22. doi:10.1002/rcm.3403.
- R.P. Shah, A. Sahu, S. Singh, Identification and characterization of degradation products of irbesartan using LC-MS/TOF, MS(n), on-line H/D exchange and LC-NMR., J. Pharm. Biomed. Anal. 51; 1037–46. doi:10.1016/j.jpba.2009.11.008.
- R.P. Shah, S. Singh, Identification and characterization of a photolytic degradation product of telmisartan using LC-MS/TOF, LC-MSn, LC-NMR and on-line H/D exchange mass studies., J. Pharm. Biomed. Anal. 53; 755–61.
doi:10.1016/j.jpba.2010.05.005. - R.P. Shah, A. Sahu, S. Singh, LC-MS/TOF, LC-MSn, on-line H/D exchange and LC-NMR studies on rosuvastatin degradation and in silico determination of toxicity of its degradation products: a comprehensive approach during
drug development., Anal. Bioanal. Chem. 405; 3215–31. doi:10.1007/s00216-013-6760-1. - S. Singh, T. Handa, M. Narayanam, A. Sahu, M. Junwal,
R.P. Shah, A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products, J. Pharm. Biomed. Anal. 69; 148–173. doi:10.1016/j.jpba.2012.03.044. - V. Kumar, R.P. Shah, S. Singh, LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation
products., J. Pharm. Biomed. Anal. 47; 508–15. doi:10.1016/j.jpba.2008.01.041. - S. Mehta, R.P. Shah, S. Singh, Strategy for identification and characterization of small quantities of drug degradation products using LC and LC-MS: Application to valsartan, amodel drug, Drug Test. Anal. 2; 82–90.
doi:10.1002/dta.116. - M. Narayanam, T. Handa, P. Sharma, S. Jhajra, P.K. Muthe, P.K. Dappili,
R.P. Shah, S. Singh, Critical practical aspects in the application of liquid chromatography-mass spectrometric studies for the characterization of impurities and degradation products, J. Pharm. Biomed. Anal. 87; 191–217. doi:10.1016/j.jpba.2013.04.027. - S. Singh, B. Prasad, A.A. Savaliya, R.P. Shah, V.M. Gohil, A. Kaur, Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products
containing these drugs, TrAC – Trends Anal. Chem. 28; 13–28. doi:10.1016/j.trac.2008.09.004.
Lab
Research Scholars
Student Details
Gegal Shah
- MS Student
- 2021-2023
![IMG_20220823_170930](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG_20220823_170930.jpg)
Tejashwini Bothra
- MS Student
- 2021-2023
![NIPERA2123PA20](https://niperahm.ac.in/wp-content/uploads/2022/11/NIPERA2123PA20.jpg)
Rushikesh Suradkar
- MS Student
- 2021-2023
![NIPERA2123PA19](https://niperahm.ac.in/wp-content/uploads/2022/11/NIPERA2123PA19-scaled.jpg)
Rahul Shinde
- MS Student
- 2021-2023
![NIPERA2123PA09](https://niperahm.ac.in/wp-content/uploads/2022/11/NIPERA2123PA09.jpg)
Pavan Ingle
- MS Student
- 2021-2023
![IMG-20230329-WA0025](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-20230329-WA0025.jpg)
Purvi Saxena
- MS Student
- 2021-2023
Naveen
- MS Student
- 2021-2023
![20220731_193225_resized](https://niperahm.ac.in/wp-content/uploads/2022/11/20220731_193225_resized-scaled.jpg)
Abhishek Changdeo Suryavanshi
- MS Student
- 2021-2023
Arvind Verma
- MS Student
- 2020-2022
Ramdas Mirase
- MS Student
- 2020-2022
Rasika Dirange
- MS Student
- 2020-2022
Sachin Wagh
- MS Student
- 2020-2022
Girish Patil
- MS Student
- 2020-2022
Divya Kukreja
- MS Student
- 2020-2022
Feni kapadiya
- MS Student
- 2020-2022
Mukta Shinde
- MS Student
- 2019-2021
Rameshwari Erla
- MS Student
- 2019-2021
Sohel Ansari
- MS Student
- 2019-2021
Kalyani Sharma
- MS Student
- 2019-2021
Roshita
- MS Student
- 2019-2021
Habeeba
- MS Student
- 2019-2021
![IMG-20230329-WA0007](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-20230329-WA0007.jpg)
Shreya Gangakhedkar
- MS Student
- 2019-2021
Rajendra Reddy
- MS Student
- 2018-2020
Lokesh Sharma
- MS Student
- 2018-2020
Nancy
- MS Student
- 2018-2020
Prerna Gangakhedkar
- MS Student
- 2018-2020
![Profile](https://niperahm.ac.in/wp-content/uploads/2022/11/Profile-scaled.jpg)
Adinath Munde
- MS Student
- 2018-2020
Dalip Sharma
- MS Student
- 2018-2020
![IMG-20221103-WA0008](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-20221103-WA0008.jpg)
Arvind Verma
- PhD Scholar
- 2022-Present
![IMG-20230331-WA0000](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-20230331-WA0000.jpg)
Karimullah Shaikh
- PhD Scholar
- 2022-Present
![IMG-20230329-WA0007](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-20230329-WA0007.jpg)
Shriya Gangakhedkar
- PhD Scholar
- 2022-Present
![vjay](https://niperahm.ac.in/wp-content/uploads/2022/11/vjay.jpg)
Vijay Shivaji Bhalekar
- PhD Scholar
- 2021-Present
![IMG_20221103_131810](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG_20221103_131810-scaled.jpg)
Sumit Kumar
- PhD Scholar
- 2020-present
![sayan 1](https://niperahm.ac.in/wp-content/uploads/2022/11/sayan-1.jpg)
Sayan Chatterjee
- PhD Scholar
- 2019-Present
![c03bf65c-33ad-4a2a-9048-8f39e8aa9e6a](https://niperahm.ac.in/wp-content/uploads/2022/11/c03bf65c-33ad-4a2a-9048-8f39e8aa9e6a.jpg)
Sonali Jain
- PhD Scholar
- 2019-Present
![IMG-20230329-WA0008](https://niperahm.ac.in/wp-content/uploads/2022/11/IMG-20230329-WA0008.jpg)
Harsh Thakkar
- PhD Scholar
- 2018-present
Achievements
- Poster HILIC HRMS method for MDA more than just biomarker`s
- Oral presentation NBRCOM 2021-crotonaldehyde stress biomarker and its modification to alpha-synuclein causative of Parkinson’s disease
- 8th Prize in oral presentation in 3rd National biomedical research competition- 2021
- Startup Grant under IISC from bio incubation Centre
- Second prize secured in Poster Presentation at International Conference on Recent Trends and Future Opportunities in Pharmaceuticals at NIPER-SAS-Nagar, Punjab held on Nov 10-12, 2022. A cash prize of Rs. 7500 was rewarded