Dr. Satyasheel Sharma - National Institute of Pharmaceutical Education & Research, Ahmedabad

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Dr. Satyasheel Sharma

Dr. Satyasheel Sharma, Ph.D.

Assistant Professor , Department of Natural Products

satyasheel[dot]sharma[at]niperahm[dot]ac[dot]in, satyasheel[dot]sharma[at]niperahm[dot]res[dot]in, sharma[dot]satyasheel[at]gmail[dot]com
+91 79 66745555
NIPER-Ahmedabad, opposite Airforce Station, Palaj
Gandhinagar, Gujarat-382355

Research Interest

Our Group is interested in blending the strategies of synthetic organic chemistry along with the medicinal aspects of natural products for the development of New Chemical Entities (NCEs) against Cancer and Neurodegenerative disorders.
Total Synthesis and semi synthesis of bioactive Natural products and its structural modification via C-H functionalization and C-C coupling reactions.
Design and construction of fluorine containing scaffolds of pharmaceutical importance via C-H Bond activation. Incorporation of Fluorine into the bioactive natural product scaffolds and its biological evaluation.
Peripheral functionalization of porphyrin ring systems for photodynamic therapy.

Experience

December 2019 - Present
Assistant Professor
NIPER-Ahmedabad (INDIA)
January 2017 - December 2019
Assistant Professor (DST-INSPIRE Faculty)
NIPER-Ahmedabad (INDIA)
September 2012 – December 2016
Research Professor (Postdoctoral Research)
School of Pharmacy, Sungkyunkwan University (South Korea)
June 2012 - August 2012 (3 Months)
Postdoctoral Research
School of Pharmacy, Kyunghee University (South Korea)
July 2011 - June 2012 (1 Year)
Postdoctoral Research
Department of Chemistry, University of Ulsan (South Korea)

Honours

Awards and Grants

Start-up Research Grant (SERB-SRG) 2021: Project Title: Exploration of dual role of β-CF3-enones as directing groups/electrophile for the construction of trifluoromethylated Carbocycles as Anti-Cancer agents
DST-INSPIRE FACULTY (2016): Project Title: Design and Construction of Fluorine Containing Scaffolds via C-H Bond Activation
Awarded Fund from National Research Foundation (NRF), South Korea for Basic Research for 3 years, Project title; C-H activation for the formation of new carbon-carbon and carbon-nitrogen bond formation, Award No.: 2013058800.
KRF (Korea Research Fellowship) fellowship (foreign PhD holder) in 2015 for 5 years funded by Ministry of Science, ICT and Future Planning, South Korea.
Senior Research Fellowship (SRF), Council of Scientific and Industrial Research (CSIR), India, Jan 2010- April 2011
Junior Research Fellowship (JRF), Council of Scientific and Industrial Research (CSIR), India, Jan 2008-Dec 2009
University Grant Commission National Eligibility Test (UGC-NET), June 2007

Publications

Regioselective Pd-catalyzed decarboxylative C-6 acylation of 7-O-carbamate coumarins and their anti-inflammatory evaluation
Amardeep Singh, Monika Diwaker, Akshata Thakur, Khemchand Surana, Manjeet Chopra, Hemant Kumar, Satyasheel Sharma* Tetrahedron, 2023, 133295 (ISSN No.: 0040-4020, Impact Factor: 2.457 Link
Catalytic and Chemodivergent Synthesis of 1-Substituted 9H-Pyrrolo[1,2-a]indoles via Annulation of β-CF3 Enones with 3-Substituted Indoles
Haritha Sindhe, Nehanaz Saiyed, Akshay Kamble, Malladi Mounika Reddy, Amardeep Singh, Satyasheel Sharma* The Journal of Organic Chemistry, 2023, 88, 230-244 (ISSN No.: 0022-3263, Impact Factor: 4.198) Link
Degradation kinetics and characterization of major degradants of binimetinib employing liquid chromatography-high resolution mass spectrometry
Niraj Rajput, Fatema Soni, Amit Kumar Sahu, Tarang Jadav, Satyasheel Sharma, Pinaki Sengupta, Journal of Pharmaceutical and Biomedical Analysis, 2022, 215, 114753. (ISSN No.: 0731-7085, Impact Factor: 3.571)
High resolution mass spectrometry‐driven metabolite profiling of baricitinib to report its unknown metabolites and step‐by‐step reaction mechanism of metabolism
Megha Rachmale, Niraj Rajput, Tarang Jadav, Amit Kumar Sahu, Satyasheel Sharma, Pinaki Sengupta, Rapid Communications in Mass Spectrometry, 2022, 36, e9385. (ISSN No.: 1097-0231, Impact Factor: 2.586)
Recent Advances in the Transition-Metal Catalyzed Directed C‒H Functionalization with Fluorinated Building Blocks
Haritha Sindhe, Bharatkumar Chaudhary, Neelanjan Chowdhur, Akshay Kamble, Vivek Kumar, Aishwarya Lad, Satyasheel Sharma*, Organic Chemistry Frontiers, 2022, 9, 1742 (ISSN No.: 2052-4129, Impact Factor: 5.281)
Rhodium (III)-catalyzed synthesis of 3-trifluoromethylindanones from N-methoxybenzamides via C–H activation and Claisen/retro-Claisen reaction
Bharatkumar Chaudhary, Neeraj Kulkarni, Satyasheel Sharma*, Organic Chemistry Frontiers, 2020, 7, 1512-1519. (ISSN No.: 2052-4129, Impact Factor: 5.281)
β‐Trifluoromethyl α,β‐unsaturated Ketones: Efficient Building Blocks for Diverse Trifluoromethylated Molecules
Bharatkumar Chaudhary, Neeraj Kulkarni, Nehanaz Saiyed, Meenakshi Chaurasia, Surbhi Desai, Sagar Potkule, Satyasheel Sharma*, Advanced Synthesis & Catalysis, 2020, 362, 4794-4819. (ISSN No.: 1615- 4150, Impact Factor = 5.837).
Rh(III)-Catalyzed [3 + 2] Annulation via C–H Activation: Direct Access to Trifluoromethyl-Substituted Indenamines and Aminoindanes
Bharatkumar Chaudhary, Prashant Auti, Suchita Dattatray Shinde, Prasanna Anjaneyulu Yakkala, Deepesh Giri, and Satyasheel Sharma*, Organic Letter, 2019, 21, 8, 2763-2767 (ISSN No.: 1523-7060, Impact Factor: 6.005)
Regioselective C–H alkylation and alkenylation at the C5 position of 2-amino-1,4-naphthoquinones with maleimides under Rh(III) catalysis
Prasanna Anjaneyulu Yakkala, Deepesh Giri, Bharatkumar Chaudhary, Prashant Auti and Satyasheel Sharma*, Organic Chemistry Frontiers, 2019, 6, 2441-2446. (ISSN No.: 2052-4129, Impact Factor: 5.281)
Regioselective indole C2-alkylation using B-CF3-substituted enones under redox neutral Rh(III) catalysis
Bharatkumar Chaudhary, Monika Diwaker, Satyasheel Sharma*, Organic Chemistry Frontiers, 2018, 5, 3133-3137. (ISSN No.: 2052-4129, Impact Factor: 5.281)
Benzophenone: a ubiquitous scaffold in medicinal chemistry
Khemchand Surana, Bharatkumar Chaudhary, Monika Diwaker, Satyasheel Sharma*, Medicinal Chemical Communication, 2018, 9, 1803-1817. (ISSN No.: 2040-2511, Impact Factor: 2.495)
Cp*Rh(III)-catalyzed C(sp3)–H alkylation of 8-methylquinolines in aqueous media
Saegun Kim, Sangil Han, Jihye Park, Satyasheel Sharma, Neeraj Kumar Mishra, Hyunjung Oh, Jong Hwan Kwak, In Su Kim, Chemical Communications., 2017, 53, 3006-3009. (ISSN No.: 1359-7345, Impact Factor: 6.222)
Site-selective Cp*Rh(III)-catalyzed C–H amination of indolines with anthranils
Neeraj Kumar Mishra, Mijin Jeon, Yongguk Oh, Hyeim Jo, Jihye Park, Sangil Han, Satyasheel Sharma, Sang Hoon Han, Young Hoon Jung, In Su Kim, Organic Chemistry Frontiers, 2017, 4, 241-249. (ISSN No.: 2052-4129, Impact Factor: 5.281)
Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones
Satyasheel Sharma, Yongguk Oh, Neeraj Kumar Mishra, Umasankar De, Hyeim Jo, Richa Sachan, Hyung Sik Kim, Young Hoon Jung, In Su Kim, Journal of Organic Chemistry, 2017, 82 (7), 3359–3367 (ISSN No.: 0022-3263, Impact Factor = 4.354) SELECTED as Featured Article
Installation of α-ketocarboxylate groups to C7-position of indolines via C−H addition and oxidation approach under ruthenium catalysis
Hyeim Jo, Jihye Park, Neeraj Kumar Mishra, Mijin Jeon, Satyasheel Sharma, Hyunjung Oh, Seok-Yong Lee, Young Hoon Jung, In Su Kim, Tetrahedron, 2017, 73, 1725-1732 (ISSN No.: 0040-4020, Impact Factor: 2.457)
Recent Advances in Catalytic C (sp2)–H Allylation Reactions
Neeraj Kumar Mishra, Satyasheel Sharma, Jihye Park, Sangil Han, In Su Kim, ACS Catalysis, 2017, 7, 2821- 2847. (ISSN No.: 2155-5435, Impact Factor: 13.05)