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National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad

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Dr. Pallab Bhattacharya, Ph.D.

Associate Professor , Department of Pharmacology and Toxicology

Research Interest

  • Dr.Bhattacharya’s laboratory investigate strategies of neuroprotection following stroke by cell therapy, NCEs and drug repurposing. The lab has in vivo experimental stroke models (transient & permanent focal cerebral ischemia, global ischemia, subarachnoid hemorrhage) and in vitro [Oxygen-glucose deprivation (OGD)] working models to study hypoxia/ischemia. These models mimic human stroke condition and provides the platform for deciphering underlying associated molecular mechanisms, investigate different therapeutic options and explores the possibilities of finding biomarkers that can benefit public health. The research interest also lies with the regulatory RNA mediated stem cell engineering and nanoparticle based targeted drug delivery to the brain
  • Dr.Bhattacharya had an advanced training in stem cell biology from Marine Biological Laboratory (MBL),Woods Hole, Massachusetts USA. He has experience in mouse transgenesis and has acquired technical skills necessary to establish transgenic animals(Pronuclear injection, 2 cell injection, blastocyst injection, electroporation of zygotes and embryonic stem cell culture including transfection, selection, cloning and analysis of embryonic stem cell clones) with a latest updates on genome engineering technologies involving CRISPR/Cas9.
  • Dr.Bhattacharya is collaborating with Nobel Laureate Prof. Andrew Schally on the aspects of neuroendocrine regulation in stroke. He is also pursuing collaborative research projects with Miller School of Medicine,USA, University of Copenhagen, Denmark and INSERM, France.

Experience

  • Jun 2019-July 2019
    Visiting Scientist

    Department of Molecular Biology and Genetics, DAGMAR Danish Center for Transgenic Mice, Aarhus, Denmark

  • Jun 2017-Aug 2017
    Visiting Scientist

    Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston USA

  • Dec 2019 - Present
    Associate Professor

    NIPER-A. India

  • July 2016 - Dec 2019
    Assistant Professor

    NIPER-A. India

  • February 2016 - June 2016
    Senior Scientist

    Stem Cell Biology Laboratory, Department of Biochemistry, Pt. Jawahar Lal Nehru Memorial Medical College, Raipur, India

  • June 2012 - January 2016
    Post-Doctoral Fellow

    Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA

  • January 2009 – May 2012
    Senior Research Fellow

    School of Biomedical Engineering, Indian Institute of Technology(BHU), Varanasi, India

  • January 2007 – December 2009
    Junior Research Fellow

    School of Biomedical Engineering, Indian Institute of Technology(BHU), Varanasi, India

  • August 2006 – January 2007
    Research Fellow, School of Biomedical Engineering

    Indian Institute of Technology(BHU), Varanasi, India

Honours

Honours

  • Visiting Scientist, Harvard Medical School, Boston, USA
  • IBRO teaching faculty for IBRO Neuroscience School.
  • Visiting Scientist, Aarhus University, Denmark
  • Extramural Grant reviewer, DST, Govt. of India
  • Invited Reviewer of 30 national/international journals
  • Ph.D examiner of IISER Kolkata, NIMHANS, Mumbai University, NFSU, Assam University, JNTU
  • Invited Talk at IAN-2016,NBRC,Manesar,Gurgaon,India
  • Dr.A PJ Abdul Kalam Young Scientist Invited Talk at IABS-2017
  • Invited Talk, IBRO Neuroscience School, NEHU, Shillong,India

Awards

  • IBRO Investigator Award,10th World Congress of Neuroscience,Daegu,South Korea
  • Paul Dudley White Award by American Heart Association(AHA),USA
  • Endowment Fellowship for Stem Cell and Regenerative Medicine Course, Marine Biological Laboratory (MBL), Woods Hole Massachusetts, USA
  • Young Investigator Award, Society for Personalized Nano-Medicine, USA
  • Young Neurologist Award, European Neurological Society(ENS)
  • Top 10% Abstract Award American Heart Association(AHA), USA
  • World Federation of Neurology(WFN) International Junior Travel Award
  • IBRO International Travel Award
  • ISN-CAEN Award for training at USA
  • IIT(BHU) Student Achievement Award (2011 and 2012 consecutively)
  • BHU Vice Chancellor Award to visit USA.
  • TECHNEX-2011 (IIT-BHU) Modex award for most outstanding project
  • D.S Kothari Post-Doctoral Fellowship
  • UGC JRF/SRF at IIT(BHU), Varanasi
  • IIT-GATE (Top state ranker)
  • JNU Combined Entrance Exam for Biotechnology (CEEB), DBT Fellowship (Not Availed)

Grants

  • US/Miller International Subcontract Research grant(2019-2021)Efficacy of IA versus IV administration of GFP+MSCs following ischemic stroke in animal model.
  • DST Grant:(2016-2019); Title: Regulatory non-coding RNA mediated mesenchymal stem cell engineering: A safety and efficacy study in rodent model of cerebral ischemia.Role: Principal Investigator.
  • ISN International Return Home Grant (2017-2018); Title: Mitochondrial protection in ischemic stroke by using microRNA mediated engineered stem cells.Role: Principle Investigator.
  • DST Grant:(2017-2020); Title: Exploring the molecular mechanism of butter oil enriched nanoformulation in enhancing nasal to brain delivery and its potential role in promoting neurogenesis.Role: Co- Principal Investigator.
  • DBT Grant:(2018-2021);Title:Light amplifying carbon quantum dot embedded contact lenses for treatment of night blindness.Role: Co- Principal Investigator.

Consultancies

  • Consultant and Coordinator for the Human Stem Cell Clinical Trial at University of Miami Miller School of Medicine by Aldagen, USA
  • Consultant and Coordinator for the Human Stem Cell Clinical Trial at University of Miami Miller School of Medicine by Covidien, USA

Publications

  • Selected Research Publications (Last 5 years)
  • Datta A, Suthar P, Sarmah D, Jadhav P, Shah J, Katamneni M, Bhosale N, Gupta V, Bohra M, Baidya F, Rana N, Ghosh B, Kaur H, Borah A, Rathod R, Sengupta P, Bhattacharya P. Inosine attenuates post-stroke neuroinflammation by modulating inflammasome mediated microglial activation and polarization. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166771. doi: 10.1016/j.bbadis.2023.166771. Epub 2023 Jun 5. PMID: 37286144.
  • Sarmah D, Sarkar A, Datta A, Ghosh B, Rana N, Sahu S, Gupta V, Thongire V, Chaudhary A, Vadak N, Kaur H, Raut S, Singh U, Borah A, Bhattacharya P. Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke. ACS Chem Neurosci. 2023 Feb 15;14(4):709-724. doi: 10.1021/acschemneuro.2c00645. Epub 2023 Jan 27. PMID: 36706354.
  • Kaur H, Sarmah D, Datta A, Borah A, Yavagal DR, Bhattacharya P. Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling. Cell Stress Chaperones. 2023 Jan 9. doi: 10.1007/s12192-022-01319-4. Epub ahead of print. PMID: 36622548.
  • Kaur H, Sarmah D, Datta A, Borah A, Yavagal DR, Bhattacharya P. Endovascular Stem Cell Therapy Promotes Neuronal Remodeling to Enhance Post Stroke Recovery by Alleviating Endoplasmic Reticulum Stress Modulated by BDNF Signaling. Stem Cell Rev Rep. 2023 Jan;19(1):264-274. doi: 10.1007/s12015-022-10461-6. Epub 2022 Oct 17. PMID: 36251114.
  • Kaur H, Sarmah D, Veeresh P, Datta A, Kalia K, Borah A, Yavagal DR, Bhattacharya P. Endovascular Stem Cell Therapy Post Stroke Rescues Neurons from Endoplasmic Reticulum Stress-Induced Apoptosis by Modulating Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Signaling. ACS Chem Neurosci. 2021 Oct 6;12(19):3745-3759. doi: 10.1021/acschemneuro.1c00506. Epub 2021 Sep 23. Erratum in: ACS Chem Neurosci. 2022 Mar 16;13(6):846. PMID: 34553602.
  • Sarmah D, Datta A, Kaur H, Kalia K, Borah A, Rodriguez AM, Yavagal DR, Bhattacharya P. Sirtuin-1 – Mediated NF-κB Pathway Modulation to Mitigate Inflammasome Signaling and Cellular Apoptosis is One of the Neuroprotective Effects of Intra-arterial Mesenchymal Stem Cell Therapy Following Ischemic Stroke. Stem Cell Rev Rep. 2022 Feb;18(2):821-838. doi: 10.1007/s12015-021-10315-7. Epub 2022 Feb 3. PMID: 35112234.
  • Sarmah D, Verma G, Datta A, Vadak N, Chaudhary A, Kalia K, Bhattacharya P. Phyllanthus emblica L. Regulates BDNF/PI3K Pathway to Modulate Glutathione for Mitoprotection and Neuroprotection in a Rodent Model of Ischemic Stroke. Cent Nerv Syst Agents Med Chem. 2022;22(3):175-187. doi: 10.2174/1871524922666220607093400. PMID: 35674296.
  • Datta A, Sarmah D, Kaur H, Chaudhary A, Mounica KL, Kalia K, Borah A, Yavagal DR, Bhattacharya P. Post-stroke Impairment of the Blood-Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway. Mol Neurobiol. 2022 May;59(5):2758-2775. doi: 10.1007/s12035-022-02761-2. Epub 2022 Feb 21. PMID: 35187613.
  • Dutta A, Phukan BC, Roy R, Mazumder MK, Paul R, Choudhury A, Kumar D, Bhattacharya P, Nath J, Kumar S, Borah A. Garcinia morella extract confers dopaminergic neuroprotection by mitigating mitochondrial dysfunctions and inflammation in mouse model of Parkinson’s disease. Metab Brain Dis. 2022 Aug;37(6):1887-1900. doi: 10.1007/s11011-022-01001-9. Epub 2022 May 27. PMID: 35622265.
  • Chetia Phukan B, Dutta A, Deb S, Saikia R, Mazumder MK, Paul R, Bhattacharya P, Sandhir R, Borah A. Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson’s disease: involvement of anti-inflammatory response. Exp Brain Res. 2022 Jan;240(1):113-122. doi: 10.1007/s00221-021-06237-y. Epub 2021 Oct 11. PMID: 34633467.
  • Vats K, Sarmah D, Datta A, Saraf J, Kaur H, Pravalika K, Wanve M, Kalia K, Borah A, Dave KR, Yavagal DR, Bhattacharya P. Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a. J Mol Neurosci. 2021 Feb;71(2):419-426. doi: 10.1007/s12031-019-01460-3. Epub 2019 Dec 9. Erratum in: J Mol Neurosci. 2021 Jan 1;: PMID: 31820348.
  • Pradhan D, Tambe V, Raval N, Gondalia P, Bhattacharya P, Kalia K, Tekade RK. Dendrimer grafted albumin nanoparticles for the treatment of post cerebral stroke damages: A proof of concept study. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110488. doi: 10.1016/j.colsurfb.2019.110488. Epub 2019 Sep 3. PMID: 31541894.
  • Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter RJ, Bhattacharya P, Cui Y, Yang H, Ma H, Yao J, Lawler SE, Zhang X, Fu J, Rozental R, Aly H, Johnson MD, Chiocca EA, Wang X. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 Jan;130:215-233. doi: 10.1016/j.freeradbiomed.2018.10.402. Epub 2018 Oct 11. PMID: 30315933.
  • Mazumder MK, Paul R, Bhattacharya P, Borah A. Neurological sequel of chronic kidney disease: From diminished Acetylcholinesterase activity to mitochondrial dysfunctions, oxidative stress and inflammation in mice brain. Sci Rep. 2019 Feb 28;9(1):3097. doi: 10.1038/s41598-018-37935-3. PMID: 30816118; PMCID: PMC6395638.
  • Saraf J, Sarmah D, Vats K, Kaur H, Pravalika K, Wanve M, Kalia K, Borah A, Dave KR, Yavagal DR, Bhattacharya P. Intra-arterial stem cell therapy modulates neuronal calcineurin and confers neuroprotection after ischemic stroke. Int J Neurosci. 2019 Oct;129(10):1039-1044. doi: 10.1080/00207454.2019.1633315. Epub 2019 Jul 1. PMID: 31203689.
  • Pravalika K, Sarmah D, Kaur H, Vats K, Saraf J, Wanve M, Kalia K, Borah A, Yavagal DR, Dave KR, Bhattacharya P. Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke. Life Sci. 2019 Jan 1;216:49-58. doi: 10.1016/j.lfs.2018.11.014. Epub 2018 Nov 7. PMID: 30414429.
  • Paul R, Dutta A, Phukan BC, Mazumder MK, Justin-Thenmozhi A, Manivasagam T, Bhattacharya P, Borah A. Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice. Neuroscience. 2018 Sep 15;388:347-356. doi: 10.1016/j.neuroscience.2018.07.041. Epub 2018 Aug 1. PMID: 30075243.
  • Paul R, Phukan BC, Justin Thenmozhi A, Manivasagam T, Bhattacharya P, Borah A. Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson’s disease. Life Sci. 2018 Jan 1;192:238-245. doi: 10.1016/j.lfs.2017.11.016. Epub 2017 Nov 11. PMID: 29138117.
  • Kanta Pravalika, Deepaneeta Sarmah, Harpreet Kaur, Kanchan Vats, Jackson Saraf, Madhuri Wanve, Kiran Kalia, Anupom Borah, Dileep R.Yavagal, Kunjan R.Dave,Pallab Bhattacharya. (2018) Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke, Life Sciences. https://doi.org/10.1016/j.lfs.2018.11.014
    • Selected Review Publications (Last 5 years)
    • Datta A, Saha C, Godse P, Sharma M, Sarmah D, Bhattacharya P. Neuroendocrine regulation in stroke. Trends Endocrinol Metab. 2023 May;34(5):260-277. doi: 10.1016/j.tem.2023.02.005. Epub 2023 Mar 13. PMID: 36922255. (Impact Factor: 13.3).

      • Saraf J, Kalia K, Borah A, Sarmah D, Kaur H, Dave KR, Yavagal DR, Bhattacharya P. A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders. ACS Cent Sci. 2018 Jul 25;4(7):805-819. doi: 10.1021/acscentsci.8b00230. Epub 2018 Jun 27. PMID: 30062109; PMCID: PMC6062828. (Impact Factor: 18.2)

      Ghosh D, Sehgal K, Sodnar B, Bhosale N, Sarmah D, Datta A, Chaudhary A, Kalia K, Wang X, Bhattacharya P. Drug repurposing for stroke intervention. Drug Discov Today. 2022Jul;27(7):1974-1982. doi: 10.1016/j.drudis.2022.03.003. Epub 2022 Mar 4. PMID: 35257857. (Impact Factor: 7.4)

      Sarmah D, Banerjee M, Datta A, Kalia K, Dhar S, Yavagal DR, Bhattacharya P. Nanotechnology in the diagnosis and treatment of stroke. Drug Discov Today. 2021 Feb;26(2):585-592.doi: 10.1016/j.drudis.2020.11.018. Epub 2020 Nov 23. PMID: 33242696. (Impact Factor: 7.4)

      Baidya F, Bohra M, Datta A, Sarmah D, Shah B, Jagtap P, Raut S, Sarkar A, Singh U, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P. Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases. Immunology. 2021 Feb;162(2):160-178. doi: 10.1111/imm.13264. Epub 2020 Oct 6. PMID: 32939758; (Impact Factor: 6.4)

      Bhattacharya P, Sarmah D, Dave KR, Goswami A, Watanabe M, Wang X, Kalia K, Plesnila N, Yavagal DR, Alvarez O. Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries. J Neurol Sci. 2021 Aug 15;427:117510. doi: 10.1016/j.jns.2021.117510. Epub 2021 May 26. PMID: 34077859. (Impact Factor: 6.0)

      Datta A, Sarmah D, Mounica L, Kaur H, Kesharwani R, Verma G, Veeresh P, Kotian V, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P. Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy. Transl Stroke Res. 2020 Dec;11(6):1185-1202. doi: 10.1007/s12975-020-00806-z. Epub 2020 Mar 26. PMID: 32219729. (Impact Factor: 6.9)

      Saraf J, Kalia K, Bhattacharya P, Tekade RK. Growing synergy of nanodiamonds in neurodegenerative interventions. Drug Discov Today. 2019 Feb;24(2):584-594. doi: 10.1016/j.drudis.2018.10.012. Epub 2018 Nov 5. PMID: 30408527. (Impact Factor: 7.4)

      Sarmah D, Kaur H, Saraf J, Vats K, Pravalika K, Wanve M, Kalia K, Borah A, Kumar A, Wang X, Yavagal DR, Dave KR, Bhattacharya P. Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy. Transl Stroke Res. 2018 Jun 20. doi: 10.1007/s12975-018-0642-y. Epub ahead of print. PMID: 29926383. (Impact Factor: 6.9)

      Sarmah D, Kaur H, Saraf J, Pravalika K, Goswami A, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P. Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell. Transl Stroke Res. 2018 Aug;9(4):356-374. doi: 10.1007/s12975-017-0580-0. Epub 2017 Oct 26. PMID: 29075984. (Impact Factor: 6.9)

      Sarmah D, Agrawal V, Rane P, Bhute S, Watanabe M, Kalia K, Ghosh Z, Dave KR, Yavagal DR, Bhattacharya P. Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies. Clin Pharmacol Ther. 2018 Jun;103(6):990-998. doi: 10.1002/cpt.927. Epub 2017 Dec 14. PMID: 29090465. (Impact Factor: 7.05)

      Sylaja PN, Srivastava MVP, Shah S, Bhatia R, Khurana D, Sharma A, Pandian JD, Kalia K, Sarmah D, Nair SS, Yavagal DR, Bhattacharya P. The SARS-CoV-2/COVID-19 pandemic and challenges in stroke care in India. Ann N Y Acad Sci. 2020 Aug;1473(1):3-10. doi: 10.1111/nyas.14379. Epub 2020 May 12. PMID: 32396683; PMCID: PMC7273096.(Impact Factor: 6.2)

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