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नेशनल इंस्टीट्यूट ऑफ फार्मास्युटिकल एजुकेशन एंड रिसर्च (नाईपर) - अहमदाबाद

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डॉ. सत्यशील शर्मा, पीएच.डी.

सहायक प्रोफेसर , प्राकृतिक उत्पाद विभाग

अनुसंधान हित

  • Our Group is interested in blending the strategies of synthetic organic chemistry along with the medicinal aspects of natural products for the development of New Chemical Entities (NCEs) against Cancer and Neurodegenerative disorders.
  • Total Synthesis and semi synthesis of bioactive Natural products and its structural modification via C-H functionalization and C-C coupling reactions.
  • Design and construction of fluorine containing scaffolds of pharmaceutical importance via C-H Bond activation. Incorporation of Fluorine into the bioactive natural product scaffolds and its biological evaluation.
  • Peripheral functionalization of porphyrin ring systems for photodynamic therapy.

Experience

  • December 2019 - Present
    Assistant Professor

    NIPER-Ahmedabad (INDIA)

  • January 2017 - December 2019
    Assistant Professor (DST-INSPIRE Faculty)

    NIPER-Ahmedabad (INDIA)

  • September 2012 – December 2016
    Research Professor (Postdoctoral Research)

    School of Pharmacy, Sungkyunkwan University (South Korea)

  • June 2012 - August 2012 (3 Months)
    Postdoctoral Research

    School of Pharmacy, Kyunghee University (South Korea)

  • July 2011 - June 2012 (1 Year)
    Postdoctoral Research

    Department of Chemistry, University of Ulsan (South Korea)

Honours

Awards

  • DST-INSPIRE FACULTY (2016): Project Title: Design and Construction of Fluorine Containing Scaffolds via C-H Bond Activation
  • Awarded Fund from National Research Foundation (NRF), South Korea for Basic Research for 3 years, Project title; C-H activation for the formation of new carbon-carbon and carbon-nitrogen bond formation, Award No.: 2013058800.
  • KRF (Korea Research Fellowship) fellowship (foreign PhD holder) in 2015 for 5 years funded by Ministry of Science, ICT and Future Planning, South Korea.
  • Senior Research Fellowship (SRF), Council of Scientific and Industrial Research (CSIR), India, Jan 2010- April 2011
  • Junior Research Fellowship (JRF), Council of Scientific and Industrial Research (CSIR), India, Jan 2008-Dec 2009
  • University Grant Commission National Eligibility Test (UGC-NET), June 2007

Publications

  • Prasanna Anjaneyulu Yakkala, Deepesh Giri, Bharatkumar Chaudhary and Prashant Auti,Satyasheel Sharma. (2019) Regioselective C–H Alkylation and Alkenylation at C5 Position of 2-Amino-1,4-Naphthoquinones with Maleimides
    Under Rh(III) Catalysis, Organic Chemistry Frontiers. Doi. 10.1039/C9QO00538B (Advance Article)(I.F 5.455)
  • Bharatkumar Chaudhary , Prashant Auti, Suchita Dattatray Shinde, Prasanna Anjaneyulu Yakkala, Deepesh Giri, andSatyasheel Sharma. (2019) Rh(III)-Catalyzed [3 + 2] Annulation via C–H Activation: Direct Access to Trifluoromethyl-Substituted
    Indenamines and Aminoindanes, organic letters. 21 (8), 2763–2767. DOI: 1021/acs.orglett.9b00720 (I.F 6.492)
  • Bharatkumar Chaudhary, Monika Diwaker and Satyasheel Sharma.(2018) Regioselective indole C2-alkylation using β-CF3-substituted enones under redox neutral Rh(III) catalysis, Organic Chemistry Frontiers. 21 (18),3133-3137
    .1039/C8QO00932E.
  • Khemchand Surana, Bharatkumar Chaudhary , Monika Diwaker and
    Satyasheel Sharma
    . (2018) Benzophenone: A Ubiquitous Scaffold in Medicinal Chemistry, MedChemComm.11(9), 1803-1817. 10.1039/C8MD00300A.
  • Recent Advances in Catalytic C (sp2)–H Allylation Reactions
    Neeraj Kumar Mishra, Satyasheel Sharma, Jihye Park, Sangil Han, In Su Kim, ACS Catalysis,2017,
    7, 2821-2847
  • Rhodium-Catalyzed [3 + 2] Annulation of Cyclic N‑Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones
    Satyasheel Sharma, Yongguk Oh, Neeraj Kumar Mishra, Umasankar De, Hyeim Jo, Richa Sachan, Hyung Sik Kim, Young Hoon Jung, In Su Kim, J. Org. Chem., 2017, 82 (7), pp 3359–3367 (Impact Factor = 4.785) SELECTED as Featured
    Article.
  • Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration
    Satyasheel Sharma, Sang Hoon Han, Yongguk Oh, Neeraj Kumar Mishra, Suk Hun Lee, Joa Sub Oh, In Su Kim, Org. Lett. 2016, 18, 2568−2571.
  • Mild and Site-Selective Allylation of Enol Carbamates with Allylic Carbonates under Rhodium Catalysis
    Satyasheel Sharma, Sang Hoon Han, Yongguk Oh, Neeraj Kumar Mishra, Sangil Han, Jong Hwan Kwak, Seok-Yong Lee, Young Hoon Jung, In Su Kim, J. Org. Chem. 2016, 81, 2243−2251.
  • Rh(III)-catalyzed direct coupling of azobenzenes with α‑diazoesters: facile synthesis of cinnolin-3(2H)-ones
    Satyasheel Sharma, Sang Hoon Han, Sangil Han, Wontae Ji, Jongchan Oh, Seok-Yong Lee, Joa Sub Oh, Young Hoon Jung, In Su Kim, Org. Lett., 2015, 17(11), 2852-2855.
  • Rh-catalyzed oxidative C–C bond formation and C–N bond cleavage: direct access to C2-olefinated free (NH)-indoles and pyrroles
    Satyasheel Sharma, Sangil Han, Mirim Kim, Neeraj Kumar Mishra, Jihye Park, Youngmi Shin, Jimin Ha, Jong Hwan Kwak, Young Hoon Jung, In Su Kim, Org. Biomol. Chem., 2014, 12, 1703–1706.
  • Pd(II)-catalyzed direct C–H acylation of N-Boc hydrazones with aldehydes: one-pot synthesis of 1,2-diacylbenzenes
    Satyasheel Sharma, Aejin Kim, Jihye Park, Mirim Kim, Jong Hwan Kwak, Young Hoon Jung, Jung Su Park, and In Su Kim, Org. Biomol. Chem., 2013, 11, 7869–7876.
  • Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature
    Satyasheel Sharma, Aejin Kim, Eonjeong Park, Jihye Park, Minyoung Kim, Jong Hwan Kwak, Sang Hwi Lee, Young Hoon Jung, In Su Kim, Advanced Synthesis & Catalysis, 2013,355, 4, 667–672.
  • Palladium-catalyzed oxidative acylation of N-benzyltriflamides with aldehydes via C–H bond activation
    Satyasheel Sharma, Jihye Park, Eonjeong Park, Aejin Kim, Minyoung Kim, Jong Hwan Kwak, Young Hoon Jung, In Su Kim, Advanced Synthesis & Catalysis, 2013, 355, 2-3, 332–336.
  • Tandem Rh(III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: the direct synthesis of 3-hydroxyisoindolin-1-ones
    Satyasheel Sharma, Eonjeong Park, Jihye Park, In Su Kim, Org. Lett., 2012, 14, 3, 906-909.
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