नेशनल इंस्टीट्यूट ऑफ फार्मास्युटिकल एजुकेशन एंड रिसर्च (नाईपर) - अहमदाबाद

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प्रभात_उपाध्याय

डॉ. प्रभात उपाध्याय, पीएचडी

सहायक प्रोफेसर , फार्मेकोलॉजी और टोक्सीकोलॉजी विभाग

  • gmailIcon prabhat[dot]upadhyay[at]niperahm[dot]res[dot]in
  • bullingनाइपर अहमदाबाद वायु सेना स्टेशन के सामने, पालेज
  • locationIconगांधीनगर, गुजरात, भारत – 382355

अनुसंधान हित

  • Photomedicine (Low level light).
  • Phytomedicine (Phytopharmaceuticals).
  • Alzheimer’s disease.
  • Microbiota (Gut/oral/vaginal/skin).
  • Irritable bowel disease.
  • Metabolic disorders (Diabetes & Obesity).
  • Inflammation/Osteoarthritis.
  • Muscular dystrophy.

Experience

  • दिसंबर 2025-वर्तमान
    सहायक प्रोफेसर

    एनआईपीईआर-अहमदाबाद, पलाज, गांधीनगर

  • सितंबर 2025 – दिसंबर 2025
    पोस्टडॉक्टोरल फेलो

    हार्वर्ड मेडिकल स्कूल एवं मैसाचुसेट्स जनरल हॉस्पिटल, वेलमैन सेंटर फॉर फोटोडर्मेटोलॉजी (वू लैब) बोस्टन, अमेरिका

  • मई 2024 – अगस्त 2025
    पोस्टडॉक्टोरल फेलो

    हार्वर्ड मेडिकल स्कूल / मैसाचुसेट्स जनरल हॉस्पिटल ,विन्सेंट सेंटर फॉर रिप्रोडक्टिव बायोलॉजी (एडलो लैब) बोस्टन, अमेरिका

  • दिसंबर 2021 – अप्रैल 2024
    पोस्टडॉक्टोरल फेलो

    हार्वर्ड मेडिकल स्कूल / मैसाचुसेट्स जनरल हॉस्पिटल, वेलमैन सेंटर फॉर फोटोडर्मेटोलॉजी (वू लैब) बोस्टन, अमेरिका

  • अक्टूबर 2018 – अक्टूबर 2021
    यंग साइंटिस्ट

    नेशनल इंस्टीट्यूट ऑफ इम्यूनोलॉजी, नई दिल्ली, भारत

  • अप्रैल 2018 – अक्टूबर 2021
    वैज्ञानिक सह मैनेजर

    आर एंड डी, जिऑन लाइफसाइंसेज़ लिमिटेड, हिमाचल प्रदेश

Publications

  • Upadhyay P, Kumar S, Chellammal HSJ, Sahu N, Srivastava S, Kumar R, Gasmi A. Gut Microbiota and Dietary Strategies for Age-Related Diseases. Mol Nutr Food Res. 2025 Dec;69(24):e70308. doi: 10.1002/mnfr.70308. Epub 2025 Nov 6. Review. PubMed PMID: 41195914.
  • Banstola A, Gao S, Zhang Z, Dong Y, Upadhyay P, Zhang Q, Li Y, Lin ZT, Wang Z, Wu MX. Light Metabolically Reprograms CD8(+) T Cells to Potentiate STING-Driven Tumor Eradication and Prevent Metastasis. Adv Sci (Weinh). 2026 Jan;13(1):e15121. doi: 10.1002/advs.202515121. Epub 2025 Oct 23. PubMed PMID: 41126739; PubMed Central PMCID: PMC12767170.
  • Upadhyay P, Suhail A, Khanal P, Kumar S. Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases. Front Immunol. 2025;16:1637191. doi: 10.3389/fimmu.2025.1637191. eCollection 2025. Review. PubMed PMID: 41132677; PubMed Central PMCID: PMC12540116.
  • Upadhyay P, Banstola A, Bhayana B, Wu MX. Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota. Adv Sci (Weinh). 2025 Dec;12(46):e11582. doi: 10.1002/advs.202511582. Epub 2025 Sep 23. PubMed PMID: 40985334; PubMed Central PMCID: PMC12697884.
  • Kumar S, Sahu N, Jawaid T, Jayasingh Chellammal HS, Upadhyay P. Dual role of lactate in human health and disease. Front Physiol. 2025;16:1621358. doi: 10.3389/fphys.2025.1621358. eCollection 2025. Review. PubMed PMID: 40821941; PubMed Central PMCID: PMC12354575.
  • Upadhyay P, Kumar S. Diabetes and Bone Health: A Comprehensive Review of Impacts and Mechanisms. Diabetes Metab Res Rev. 2025 Jul;41(5):e70062. doi: 10.1002/dmrr.70062. Review. PubMed PMID: 40557919.
  • Vatsavai N, Kaur Bhinder S, Shaik R, Mahira S, Kapoor S, Ali MS, Verma D, Singh J, Badavenkatappa Gari S, Upadhyay P, Meshkovska Y, Godugu C, Thatikonda S, Pooladanda V. Advances and challenges in cancer immunotherapy: mechanisms, clinical applications, and future directions. Front Pharmacol. 2025;16:1602529. doi: 10.3389/fphar.2025.1602529. eCollection 2025. Review. PubMed PMID: 40584631; PubMed Central PMCID: PMC12202542.
  • Lin ZT, Jana B, Korupolu S, Kong Y, Liu G, Dong Y, Li Y, Zhang Q, Shou W, Upadhyay P, Wang Z, Ran Z, Wu MX. Wearable Photonic Device for Multiple Biomarker Sampling and Detection without Blood Draws. Adv Mater. 2025 Jul;37(27):e2416240. doi: 10.1002/adma.202416240. Epub 2025 May 6. PubMed PMID: 40326959.
  • Singh AK, Kumar P, Mishra SK, Rajput VD, Tiwari KN, Singh AK, Minkina T, Pandey AK, Upadhyay P. A Dual Therapeutic Approach to Diabetes Mellitus via Bioactive Phytochemicals Found in a Poly Herbal Extract by Restoration of Favorable Gut Flora and Related Short-Chain Fatty Acids. Appl Biochem Biotechnol. 2024 Oct;196(10):6690-6715. doi: 10.1007/s12010-024-04879-6. Epub 2024 Feb 23. PubMed PMID: 38393580.
  • Upadhyay P, Kalra D, Nilakhe AS, Aggrawal V, Gupta S. Polyherbal formulation PL02 alleviates pain, inflammation, and subchondral bone deterioration in an osteoarthritis rodent model. Front Nutr. 2023;10:1217051. doi: 10.3389/fnut.2023.1217051. eCollection 2023. PubMed PMID: 38045809; PubMed Central PMCID: PMC10693428.
  • Upadhyay P, Tyagi A, Agrawal S, Kumar A, Gupta S. Bidirectional Effect of Triphala on Modulating Gut-Brain Axis to Improve Cognition in the Murine Model of Alzheimer’s Disease. Mol Nutr Food Res. 2024 Jul;68(13):e2300104. doi: 10.1002/mnfr.202300104. Epub 2023 Sep 28. PubMed PMID: 37767948.
  • Upadhyay P, Gupta S. Dual mode of Triphala in the reversal of cognition through gut restoration in antibiotic mediated prolonged dysbiosis condition in 5XFAD mice. Exp Neurol. 2023 Sep;367:114473. doi: 10.1016/j.expneurol.2023.114473. Epub 2023 Jun 28. PubMed PMID: 37385519.
  • Sharma P, Verma N, Verma A, Wal A, Kumar S, and Upadhyay P*. Lifestyle, Diet, and the Gut-Brain Axis in Neuroprotection (Chapter 16). Neuroinflammation and Autophagy in Neurodegeneration. Springer. 2025. ISBN 978-981-95-3945-1. 259-271.
  • Upadhyay P, Suhail A, and Kumar S. Advanced Delivery Systems and Gene Editing in Neurotherapeutics (Chapter 15). Neuroinflammation and Autophagy in Neurodegeneration. Springer. 2025. ISBN 978-981-95-3945-1. 243-258.
  • Tkaur A, Gosh D, Sarkar R, Averbek S, Iyaswamy A, Upadhyay P, Gupta S. The Neuroinflammation Enigma: Cracking the Code of the Gut-Brain Connection (Chapter 14). Gastrointestinal Inflammations and Gut Microbiota Pathophysiology, Management, and Emerging Therapies. Routledge Taylor & Francis Group. 2025; 1: 251-261.
  • Sahu N & Upadhyay P*. Phytochemical-based Drugs for Salmonella Biofilm Disruption (Chapter 7). Salmonella Biofilms: Formation, Resistance, and Therapeutics. The Royal Society of Chemistry. 2025. ISBN 978-1-83767-704-7: 123-143.
  • Upadhyay P, Kalra D, Gupta S, Mishra S K. Reversal of metabolic disorder through the restoration of gut microbiota (Chapter 14). Gut Microbiome in Neurological Health and Disorders. Nutritional Neurosciences. Springer. 2022. Online ISBN 978-981-19-4530-4. Page 179-193.
  • Sahu N, Upadhyay P*, Mishra SK. Role of Short-Chain Fatty Acids from Gut Microbiota in Neuroendocrine Pathogenesis Management. Gut Microbiome in Neurological Health and Disorders. Nutritional Neurosciences. Springer. 2022. Online ISBN 978-981-19-4530-4. Page 139-151.
  • Upadhyay P, Shukla R, Mishra SK, Dubey GP, Verma R, Purohit S. Medicinal Roles of Phytomolecules in the Treatment and Management of Cancer (Chapter 15). Phytochemistry, Volume 2: Pharmacognosy, Nanomedicine, and Phytochemicals. CRC Press, 2018. ISBN 9781771887601. Page 333-366.
  • Shukla R, Tripathi YB, Upadhyay P. Medicinal Roles of Phytomolecules in the Treatment and Management of Diabetic Nephropathy (Chapter 18). Phytochemistry, Vol 2: Pharmacognosy, Nanomedicine, and Contemporary Issues. CRC Press, 2018. ISBN 9781771887601. Page 407-426.
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